Dermatology Department, Hedi Chaker University Hospital, Sfax, Tunisia.
J Cosmet Dermatol. 2022 Oct;21(10):4225-4233. doi: 10.1111/jocd.15050. Epub 2022 May 23.
Vitiligo is an autoimmune disorder characterized by loss of epidermal melanocytes. It has cosmetic and psychosocial impact. The objective of this paper is to evaluate the interest of platelet-rich-plasma in the treatment of vitiligo.
We conducted a prospective study between January 2019 and September 2021.
Our descriptive study included 10 patients followed-up for vitiligo refractory to conventional therapies. The mean age was 36.2 years. Sex ratio was 0.25. Prior to platelet-rich-plasma treatment, vitiligo was stable in all cases. The mean number of platelet-rich-plasma sessions received by our patients was 2.6 (1-6). A visible improvement of lesions was obtained after a mean of 1.5 sessions. 40% of patients had obtained repigmentation of more than 50% for at least one lesion. An improvement of more than 75% (grade 4) was noted in 2 cases after a mean duration of 5.5 sessions. 40% of patients had obtained repigmentation of more than 50% for at least one lesion. A percentage of improvement between 50 and 74% (grade 3) was obtained for 2 patients. Four patients had an improvement of less than 25% (grade 1) after a mean of 1.75 sessions. There was no recurrence of depigmentation after a mean follow-up of 6 months (1 to 24 months).
Our series proves the benefit of platelet-rich-plasma in the treatment of vitiligo. It is a safe and promising option for stable lesions in different body sites with few side effects.
白癜风是一种以表皮黑色素细胞丧失为特征的自身免疫性疾病。它会对患者的容貌和心理产生影响。本文旨在评估富血小板血浆在白癜风治疗中的作用。
我们进行了一项前瞻性研究，纳入了 2019 年 1 月至 2021 年 9 月期间接受治疗的 10 例白癜风患者。
我们的描述性研究共纳入 10 例经常规治疗无效的白癜风患者。患者的平均年龄为 36.2 岁，男女比例为 0.25。在接受富血小板血浆治疗前，所有患者的白癜风均处于稳定期。患者接受富血小板血浆治疗的平均次数为 2.6 次（1-6 次）。平均治疗 1.5 次后，患者的皮损可见改善。40%的患者至少有 1 处皮损的复色率超过 50%。2 例患者在接受平均 5.5 次治疗后复色率超过 75%（4 级）。40%的患者至少有 1 处皮损的复色率超过 50%。2 例患者复色率在 50%至 74%之间（3 级）。4 例患者在接受平均 1.75 次治疗后复色率小于 25%（1 级）。平均随访 6 个月（1-24 个月）后，无复色患者。
本研究证明了富血小板血浆治疗白癜风的有效性。对于不同部位稳定的皮损，富血小板血浆是一种安全、有前景的治疗选择，且副作用较少。
