School of Public Health and Health Sciences Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA, 01003, USA.
School of Applied Meteorology, Nanjing University of Information Science and Technology (NUIST), Nanjing, 210044, China.
Biogerontology. 2022 Jun;23(3):381-384. doi: 10.1007/s10522-022-09964-z. Epub 2022 May 7.
This article argues that evolution and the concept of hormesis are biologically inseparable. It proposes that evolutionary processes led to the selection of inducible adaptive hormetic strategies that are necessary for wellbeing and survival. Hormesis has been demonstrated in essentially all organisms in which it has been studied from bacteria to humans, showing its highly conserved features. This evolution-hormesis integration should be a central feature in both understanding the biology of aging but also in ways to enhance improved health-based aging strategies.
本文认为，进化和适应原效应这两个概念在生物学上是不可分割的。它提出，进化过程导致了诱导适应性适应原策略的选择，这些策略对于生存和健康是必要的。从细菌到人类，几乎所有研究过的生物中都已经证明了适应原效应的存在，这表明它具有高度保守的特征。这种进化-适应原效应的整合应该是理解衰老生物学的一个核心特征，也是增强基于健康的衰老策略的关键。
