Center for Evaluation and Surveys Research, National Institute of Public Health, Av. Universidad #655. Colonia Santa María Ahuacatitlan, ZC 62100, Cuernavaca, Mor, Mexico.
Center for Infectious Diseases, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
BMC Geriatr. 2022 May 7;22(1):403. doi: 10.1186/s12877-022-03091-7.
Maintenance of physical performance is essential for achievement of healthy aging. A few studies have explored the association between inflammatory markers and physical performance in older adults with inconclusive results. Our aim was to analyze the association of tumor necrosis factor-alpha (TNF-α), Interleukin-10 (IL-10), and C-reactive protein (CRP) with physical performance in a sample of older adults in rural settings of Mexico.
Our study comprised 307 community-dwelling older men and women who participated in the third wave of the Rural Frailty Study. We assessed the physical performance with the Short Physical Performance Battery (SPPB) and classified older adults as low performance if SPPB scored ≤8. Inflammatory markers were ascertained using serum by immunodetection methods. Logistic regression models were used to estimate the associations between inflammatory markers and physical performance.
In comparison with the normal physical performance group, low physical performance individuals mainly were female (P < 0.01), older (P < 0.01), more illiterate (P = 0.02), more hypertensive (P < 0.01), fewer smokers (P = 0.02), and had higher CRP levels (P < 0.01). The logistic model results showed a significant association between the 3rd tertile of CRP and low physical performance (OR = 2.23; P = 0.03). IL-10 and TNF-α levels did not show a significant association.
The results of this study were mixed, with a significant association of physical performance with higher CRP levels but nonsignificant with IL-10 and TNF-α. Further studies with improved designs are needed by incorporating a broader set of inflammatory markers.
保持身体机能对于实现健康老龄化至关重要。一些研究探讨了炎症标志物与老年人身体机能之间的关系，但结果并不一致。我们旨在分析肿瘤坏死因子-α（TNF-α）、白细胞介素-10（IL-10）和 C 反应蛋白（CRP）与墨西哥农村地区老年人身体机能之间的关系。
我们的研究纳入了 307 名居住在社区的老年男女，他们参加了农村衰弱研究的第三波调查。我们使用简短身体表现电池（SPPB）评估身体机能，并将 SPPB 评分≤8 的老年人归类为低身体机能。使用免疫检测方法通过血清来确定炎症标志物。使用逻辑回归模型来估计炎症标志物与身体机能之间的关系。
与正常身体机能组相比，低身体机能个体主要为女性（P < 0.01）、年龄较大（P < 0.01）、文化程度较低（P = 0.02）、高血压患者较多（P < 0.01）、吸烟者较少（P = 0.02）和 CRP 水平较高（P < 0.01）。逻辑模型结果显示 CRP 第 3 tertile 与低身体机能之间存在显著关联（OR = 2.23；P = 0.03）。IL-10 和 TNF-α 水平与低身体机能无显著关联。
本研究结果喜忧参半，CRP 水平与身体机能显著相关，但与 IL-10 和 TNF-α 不相关。需要进一步进行设计改进的研究，纳入更广泛的炎症标志物。
