Infection Control Convergence Research Center, Chungnam National University College of Medicine, Daejeon, 35015, Korea.
Department of Microbiology, Chungnam National University College of Medicine, Daejeon, 35015, Korea.
J Hematol Oncol. 2022 May 7;15(1):51. doi: 10.1186/s13045-022-01262-y.
Acute myeloid leukemia (AML) is a severe hematologic malignancy prevalent in older patients, and the identification of potential therapeutic targets for AML is problematic. Autophagy is a lysosome-dependent catabolic pathway involved in the tumorigenesis and/or treatment of various cancers. Mounting evidence has suggested that autophagy plays a critical role in the initiation and progression of AML and anticancer responses. In this review, we describe recent updates on the multifaceted functions of autophagy linking to genetic alterations of AML. We also summarize the latest evidence for autophagy-related genes as potential prognostic predictors and drivers of AML tumorigenesis. We then discuss the crosstalk between autophagy and tumor cell metabolism into the impact on both AML progression and anti-leukemic treatment. Moreover, a series of autophagy regulators, i.e., the inhibitors and activators, are described as potential therapeutics for AML. Finally, we describe the translation of autophagy-modulating therapeutics into clinical practice. Autophagy in AML is a double-edged sword, necessitating a deeper understanding of how autophagy influences dual functions in AML tumorigenesis and anti-leukemic responses.
急性髓系白血病（AML）是一种常见于老年患者的严重血液系统恶性肿瘤，寻找 AML 的潜在治疗靶点是一个难题。自噬是一种溶酶体依赖性的分解代谢途径，与多种癌症的发生和/或治疗有关。越来越多的证据表明，自噬在 AML 的发生和进展以及抗癌反应中起着关键作用。在这篇综述中，我们描述了自噬的多方面功能的最新进展，这些功能与 AML 的遗传改变有关。我们还总结了自噬相关基因作为 AML 肿瘤发生的潜在预后预测因子和驱动因子的最新证据。然后，我们讨论了自噬与肿瘤细胞代谢之间的串扰对 AML 进展和抗白血病治疗的影响。此外，还描述了一系列自噬调节剂，即抑制剂和激活剂，作为 AML 的潜在治疗方法。最后，我们描述了自噬调节治疗在临床实践中的转化。AML 中的自噬是一把双刃剑，需要更深入地了解自噬如何影响 AML 肿瘤发生和抗癌反应中的双重功能。
