Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA,
J Avian Med Surg. 2022 May;36(1):53-57. doi: 10.1647/20-00096.
Currently, drug-induced stimulation of appetite is not commonly performed in hyporexic or anorexic companion psittacine birds. Instead, to prevent a catabolic state and weight loss, supplemental feedings are routinely performed by crop gavage. However, crop gavage is not without complications and is stressful to the patient and labor intensive. The objective of this study was to evaluate the effect of midazolam on food intake in healthy budgerigars. In a randomized, blinded, controlled study, change in food intake after intramuscular administration of midazolam (1 mg/kg) or a placebo-control treatment (0.9% saline) was evaluated in 12 healthy adult budgerigars (). Food intake was quantified for 1 hour before and after drug administration. Birds were monitored for feeding behavior as well as signs of sedation. After midazolam administration, a median 6-fold (1.1-28) increase in food intake was recorded. In 3 of 6 (50%) birds, the food intake increase after midazolam administration was >10-fold (median 17-fold [10-28]), whereas in the remaining 3 birds, food intake increased by only 1.7-fold (1.1-1.8). The median amount of food ingested (16.7 g/kg [3.2-43.2 g/kg]) was significantly higher after midazolam administration compared with the control group (1.9 g/kg [0.0-19.7 g/kg], = .015). The median time birds spent displaying feeding behavior after the midazolam injection was 18% (0-43%), compared with 1% (0-20%) in the control group after saline injection. Five of 6 (83%) birds showed signs consistent with mild sedation after midazolam administration. This study demonstrates that midazolam is an appetite stimulant in budgerigars. Future studies are needed to evaluate whether midazolam's effects on food intake are dose dependent and whether the duration of effect exceeds 1 hour.
目前，在厌食或食欲减退的鹦鹉中，通常不会使用药物来刺激食欲。相反，为了防止分解代谢状态和体重减轻，通常通过灌食来进行补充喂养。然而，灌食并非没有并发症，而且对患者和护理人员来说都是有压力且劳动强度大的。本研究的目的是评估咪达唑仑对健康虎皮鹦鹉食物摄入量的影响。在一项随机、双盲、对照研究中，评估了 12 只健康成年虎皮鹦鹉（）肌肉内给予咪达唑仑（1mg/kg）或安慰剂对照治疗（0.9%生理盐水）后食物摄入量的变化。在药物给药前后 1 小时内定量食物摄入量。监测鸟类的进食行为以及镇静迹象。咪达唑仑给药后，记录到中位数增加 6 倍（1.1-28）的食物摄入量。在 6 只鸟中的 3 只（50%）中，咪达唑仑给药后的食物摄入量增加超过 10 倍（中位数增加 17 倍[10-28]），而在其余 3 只鸟中，食物摄入量仅增加了 1.7 倍（1.1-1.8）。与对照组（1.9g/kg[0.0-19.7g/kg]， =.015）相比，咪达唑仑给药后鸟类摄入的中位数（16.7g/kg[3.2-43.2g/kg]）明显更高。与盐水注射后的对照组（1%[0-20%]）相比，咪达唑仑注射后鸟类显示进食行为的中位数时间为 18%（0-43%）。咪达唑仑给药后，5 只鸟（83%）表现出与轻度镇静一致的迹象。本研究表明，咪达唑仑是虎皮鹦鹉的食欲刺激剂。需要进一步研究以评估咪达唑仑对食物摄入量的影响是否剂量依赖性，以及作用持续时间是否超过 1 小时。
