适应性生物反馈训练联合口服复方聚乙二醇4000电解质散治疗儿童出口梗阻型便秘的临床疗效：一项前瞻性随机对照试验
[Clinical efficacy of adaptive biofeedback training combined with oral administration of compound polyethylene glycol 4000-electrolyte powder in the treatment of children with outlet obstruction constipation: a prospective randomized controlled trial].
作者信息
Wang Rui-Feng, Zhou Fang, Wang Huan, Yu Zhi-Dan, Li Xiao-Qin
机构信息
Department of Gastroenterology, Henan Children's Hospital/Children's Hospital Affiliated to Zhengzhou University/Zhengzhou Children's Hospital/Zhengzhou Key Laboratory of Children's Digestive Diseases, Zhengzhou 450018, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2022 Apr 15;24(4):377-381. doi: 10.7499/j.issn.1008-8830.2112001.
OBJECTIVES
To study the clinical efficacy, advantages, and disadvantages of adaptive biofeedback training combined with oral administration of compound polyethylene glycol 4000-electrolyte powder in the treatment of children with outlet obstruction constipation (OOC).
METHODS
A total of 168 children with OOC were enrolled in this prospective study. All the subjects were randomly divided into a test group and a control group based on the order of visiting time, 84 in each group. The test group was treated with adaptive biofeedback training combined with oral administration of compound polyethylene glycol 4000-electrolyte powder, and the control group was treated with oral administration of compound polyethylene glycol 4000-electrolyte powder alone. Eleven children in the test group and two children in the control group withdrew from the study since they could not finish the whole treatment course. Finally, 73 children in the test group and 82 children in the control group were included in this analysis. As clinical outcomes, the total score of clinical symptoms and overall response rate were compared between the two groups at weeks 4 and 8 of treatment.
RESULTS
There was no significant difference in the total score of clinical symptoms between the two groups at beginning of treatment and at week 4 (>0.05), while the test group had a significantly lower total score of clinical symptoms than the control group at week 8 (<0.05). At week 4, there was no significant difference in overall response rate between the two groups (>0.05), while the test group had a significantly higher overall response rate than the control group at week 8 (<0.05).
CONCLUSIONS
Adaptive biofeedback training combined with oral administration of compound polyethylene glycol 4000-electrolyte powder is significantly associated with improvement of clinical outcomes in the treatment of children with OOC.
目的
探讨适应性生物反馈训练联合口服复方聚乙二醇4000电解质散治疗儿童出口梗阻型便秘（OOC）的临床疗效、优缺点。
方法
本前瞻性研究共纳入168例OOC患儿。所有受试者根据就诊时间顺序随机分为试验组和对照组，每组84例。试验组采用适应性生物反馈训练联合口服复方聚乙二醇4000电解质散治疗，对照组仅采用口服复方聚乙二醇4000电解质散治疗。试验组有11例患儿、对照组有2例患儿因无法完成整个疗程而退出研究。最终，试验组73例患儿、对照组82例患儿纳入本分析。作为临床结局指标，比较两组在治疗第4周和第8周时的临床症状总分及总体有效率。
结果
治疗开始时及第4周，两组临床症状总分比较差异无统计学意义（>0.05），但在第8周时，试验组临床症状总分显著低于对照组（<0.05）。第4周时，两组总体有效率比较差异无统计学意义（>0.05），而在第8周时，试验组总体有效率显著高于对照组（<0.05）。
结论
适应性生物反馈训练联合口服复方聚乙二醇4000电解质散治疗儿童OOC与临床结局改善显著相关。
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