Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Cell Infect Microbiol. 2022 Aug 18;12:938608. doi: 10.3389/fcimb.2022.938608. eCollection 2022.
The prevalence of infection has exceeded 50% worldwide, and it is considered a high-risk factor for chronic gastritis, peptic ulcer, gastric adenocarcinoma, gastroesophageal reflux disease and functional dyspepsia. drug resistance is a common problem worldwide. In recent years, the relationship between infection and gastrointestinal microecology has received much attention. infection changes the structure and composition of gastrointestinal microflora by regulating the gastrointestinal microecological environment, local pH value, cytokines and antimicrobial peptides, and immune response and then plays a crucial role in the occurrence and development of digestive system tumors, liver metabolism and extragastrointestinal diseases. The quadruple strategy of eradication can also aggravate gastrointestinal microflora disorder. However, probiotics can reduce intestinal flora changes and imbalances through different mechanisms, thus enhancing the efficacy of eradication therapy and reducing adverse reactions caused by eradication therapy. Therefore, this paper reviews the relationship between infection and gastrointestinal microecology and its clinical application, providing a basis for clinical treatment.
全球 感染的患病率超过 50%，它被认为是慢性胃炎、消化性溃疡、胃腺癌、胃食管反流病和功能性消化不良的高危因素。耐药性是全球普遍存在的问题。近年来，感染与胃肠道微生态的关系受到了广泛关注。感染通过调节胃肠道微生态环境、局部 pH 值、细胞因子和抗菌肽以及免疫反应，改变胃肠道微生物群落的结构和组成，从而在消化系统肿瘤、肝脏代谢和胃肠道外疾病的发生和发展中发挥关键作用。根除的四联疗法也会加重胃肠道微生物群落紊乱。然而，益生菌可以通过不同的机制减少肠道菌群的变化和失衡，从而增强根除治疗的疗效，减少根除治疗引起的不良反应。因此，本文综述了感染与胃肠道微生态的关系及其临床应用，为临床治疗提供了依据。
