Fu Yanhua, Finney Nathaniel S
School of Pharmaceutical Sciences and Technology, Health Sciences Platform, Tianjin University 92 Weijin Road, Nankai District Tianjin 300072 China
RSC Adv. 2018 Aug 14;8(51):29051-29061. doi: 10.1039/c8ra02297f.
Small-molecule fluorescent probes have become powerful tools for using light to advance the study of cell biology, discover new drugs, detect environmental contaminants, and further the detection of cancer. These applications correlate with the expansion of the fluorescent probe research community - small in the late 20 century, now a collection of more than a hundred research groups world-wide. This expansion required the entry of adventurous scientists from many other fields. This tutorial review introduces some important concepts related to fluorescent probe development. It is hoped that it will facilitate further expansion of the field by demystifying it.
小分子荧光探针已成为利用光来推动细胞生物学研究、发现新药、检测环境污染物以及促进癌症检测的有力工具。这些应用与荧光探针研究群体的扩大相关——在20世纪后期规模较小，如今已发展成为全球一百多个研究小组的集合。这一扩张需要许多其他领域富有冒险精神的科学家加入。本教程综述介绍了一些与荧光探针开发相关的重要概念。希望通过揭开其神秘面纱，促进该领域的进一步发展。
