Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People's Republic of China.
Int J Nanomedicine. 2022 May 2;17:1927-1950. doi: 10.2147/IJN.S357598. eCollection 2022.
Hemorrhagic stroke is one of the most devastating diseases worldwide due to a high rate of disability and mortality with few effective treatments. Recent advances in nanomedicines to promote hemostasis, drug delivery, neuroprotection, and nerve regeneration may provide insight into hemorrhagic stroke treatment. In this review, we first view the pathophysiology and conventional therapeutics of hemorrhagic stroke. Second, we comprehensively summarize the current nanomedicines applied in hemorrhagic stroke, including inorganic nanomaterials, polymer-based nanomaterials, lipid-based nanomaterials, self-assembling peptide-based hydrogel, exosomes, and gel systems. Finally, the challenges, opportunities, and future perspectives of nanomedicines for hemorrhagic stroke are discussed. Thus, this review promotes greater exploration of effective therapies for hemorrhagic stroke with nanomedicines.
出血性脑卒中是全球最具破坏性的疾病之一，其致残率和死亡率高，而有效的治疗方法却很少。纳米医学在促进止血、药物输送、神经保护和神经再生方面的最新进展，可能为出血性脑卒中的治疗提供新的思路。在这篇综述中，我们首先探讨了出血性脑卒中的病理生理学和传统治疗方法。其次，我们全面总结了目前应用于出血性脑卒中的纳米药物，包括无机纳米材料、基于聚合物的纳米材料、基于脂质的纳米材料、自组装肽基水凝胶、外泌体和凝胶系统。最后，讨论了纳米药物治疗出血性脑卒中的挑战、机遇和未来展望。因此，本综述促进了利用纳米药物治疗出血性脑卒中的更深入探索。
