降钙素原并非2019冠状病毒病患者入院时接受微生物学检查时合并细菌感染的可靠生物标志物。
Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission.
作者信息
Relph Katharine A, Russell Clark D, Fairfield Cameron J, Turtle Lance, de Silva Thushan I, Siggins Matthew K, Drake Thomas M, Thwaites Ryan S, Abrams Simon, Moore Shona C, Hardwick Hayley E, Oosthuyzen Wilna, Harrison Ewen M, Docherty Annemarie B, Openshaw Peter J M, Baillie J Kenneth, Semple Malcolm G, Ho Antonia
机构信息
University of Edinburgh Centre for Inflammation Research, Edinburgh, United Kingdom.
Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.
出版信息
Open Forum Infect Dis. 2022 May 1;9(5):ofac179. doi: 10.1093/ofid/ofac179. eCollection 2022 May.
Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11-1.70] ng/mL vs 0.24 [0.10-0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51-.60]).
1040例2019冠状病毒病住院成人患者（来自国际严重急性呼吸和新发感染联盟世界卫生组织临床特征方案英国研究纳入的48902例患者）有入院时降钙素原测量值和微生物学结果。虽然细菌合并感染时降钙素原较高，但这在临床上既无显著意义（中位数[四分位间距]，0.33[0.11 - 1.70]ng/mL对0.24[0.10 - 0.90]ng/mL），在诊断上也无用处（受试者工作特征曲线下面积，0.56[95%置信区间，0.51 - 0.60]）。
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