Antioxidant activity of olive flounder () surimi digest in in vitro and in vivo.

Surimi is refined myofibrillar proteins of fish, which are materials of processed seafood products. However, the health-related outcomes associated with surimi consumption need further investigation. Given the high valued impact of surimi in the functional food industry, the study aims to evaluate its digest with regard to antioxidant potential to understand health benefits raised by surimi consumption. surimi digest (POSD) showed a significant DPPH and alkyl radical scavenging activity and protective effects against 2,20-azobis (2-methylpropionamidine) dihydrochloride (AAPH)-induced oxidative stressed Vero cells with a significant increasing cell viability and decreasing apoptosis. It also dramatically suppressed the production of reactive oxygen species and lipid peroxidation as well as prevented cell death and down-regulated pro-apoptotic genes at the mRNA levels in AAPH-stimulated zebrafish. This study reports the protective effects against oxidative stressed cells and zebrafish by a strong antioxidant activity of POSD. Therefore, surimi consumption could be a potential benefit in the prevention of oxidative stress-related diseases.