Olerud J E, O'Brien W, Riederer-Henderson M A, Steiger D, Forster F K, Daly C, Ketterer D J, Odland G F
J Invest Dermatol. 1987 May;88(5):615-23. doi: 10.1111/1523-1747.ep12470221.
The aim of the present study was to test the hypothesis that ultrasonic propagation properties in skin and wound tissue would correlate with material properties such as collagen content, water content, and tensile strength of those tissues. Both ultrasonic speed and ultrasonic attenuation coefficient were directly correlated with tissue collagen content, [r = 0.80 and r = 0.56, respectively (p less than 0.001)]. In addition, ultrasonic speed and attenuation coefficient were inversely correlated with tissue water content, [r = -0.57 and r = -0.73, respectively (p less than 0.001)]. Tensile strength also correlated very significantly with ultrasonic speed (r = 0.90, p less than 0.001), and significantly with attenuation coefficient (r = 0.58, p less than 0.001). The results demonstrate the feasibility of using ultrasound for noninvasively determining the material properties of biologic tissues including healing cutaneous wounds.
皮肤和伤口组织中的超声传播特性与这些组织的材料特性（如胶原蛋白含量、含水量和拉伸强度）相关。超声速度和超声衰减系数均与组织胶原蛋白含量直接相关，[分别为r = 0.80和r = 0.56（p < 0.001）]。此外，超声速度和衰减系数与组织含水量呈负相关，[分别为r = -0.57和r = -0.73（p < 0.001）]。拉伸强度也与超声速度非常显著相关（r = 0.90，p < 0.001），与衰减系数显著相关（r = 0.58，p < 0.001）。结果表明，使用超声无创测定包括愈合中的皮肤伤口在内的生物组织的材料特性是可行的。
