[金银花质量标志物的分析与预测]
[Analysis and prediction of quality markers of Lonicerae Japonicae Flos].
作者信息
Yuan Yue, Zhang Lin-Lin, Liu Jian-Ting, Zhang Hong-Bing, Xu Jun, Zhang Tie-Jun
机构信息
Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.
Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research Tianjin 300301, China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research Tianjin 300301, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2022 Apr;47(7):1730-1738. doi: 10.19540/j.cnki.cjcmm.20211224.201.
Lonicerae Japonicae Flos, as common Chinese medicine, has been used for thousands of years in the treatment of inflammation and infectious diseases with definite efficacies. The complex composition of Lonicerae Japonicae Flos results in its extensive pharmacological effects, so the assessment of its quality by only a few index components is not comprehensive. Guided by the quality marker(Q-marker), the present study comprehensively analyzed and predicted the quality connotation of Lonicerae Japonicae Flos based on the chemical composition and component transfer, the phylogenetic relationship, chemical composition effectiveness, measurability, and specificity. Chlorogenic acid, isochlorogenic acids A, B, and C, luteoloside, rutin, sweroside, and secoxyloganin were predicted as candidate Q-markers of Lonicerae Japonicae Flos.
金银花作为常用中药，数千年来一直用于治疗炎症和传染病，疗效确切。金银花的成分复杂，药理作用广泛，仅通过少数指标成分来评价其质量并不全面。本研究以质量标志物（Q-marker）为指导，基于化学成分与成分转移、系统发育关系、化学成分有效性、可测性和特异性，对金银花的质量内涵进行了综合分析和预测。绿原酸、异绿原酸A、B、C、木犀草苷、芦丁、獐牙菜苷和裂环氧化马钱苷被预测为金银花的候选Q-标志物。
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