N6-甲基腺苷（m6A）修饰的长链非编码RNA在人类癌症中的新作用。
The emerging roles of N6-methyladenosine (m6A)-modified long non-coding RNAs in human cancers.
作者信息
Liu Jingwen, Zhao Wei, Zhang Leyu, Wang Xi
机构信息
The School and Hospital of Stomatology, Tianjin Medical University, Qixiangtai Road, No. 12, Tianjin, 300070, P.R. China.
出版信息
Cell Death Discov. 2022 May 9;8(1):255. doi: 10.1038/s41420-022-01050-0.
N-methyladenosine (mA) epitranscriptional modifications widely exist in RNA, which play critical roles in RNA metabolism and biogenesis processes. Long non-coding RNAs (lncRNAs) are class of non-coding RNAs longer than 200 nucleotides without protein-coding ability. LncRNAs participate in a large number of vital biological progressions. With the great improvement of molecular biology, mA and lncRNAs are attracting more attention from researchers and scholars. In this review, we overview the current status of mA and lncRNAs based on the latest research, and propose some viewpoints for future research perspectives.
N6-甲基腺苷（m6A）表观转录修饰广泛存在于RNA中，在RNA代谢和生物合成过程中发挥关键作用。长链非编码RNA（lncRNA）是一类长度超过200个核苷酸且无蛋白质编码能力的非编码RNA。lncRNA参与大量重要的生物学进程。随着分子生物学的巨大进步，m6A和lncRNA正吸引着越来越多研究人员和学者的关注。在本综述中，我们基于最新研究概述了m6A和lncRNA的现状，并对未来研究方向提出了一些观点。
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