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Is Indian childhood cirrhosis an extinct disease now?--An observational study.印度儿童肝硬化现在是一种绝迹的疾病了吗？——一项观察性研究。
Indian J Pediatr. 2013 Aug;80(8):651-4. doi: 10.1007/s12098-012-0935-1. Epub 2012 Dec 22.
3
Copper metabolic defects and liver disease: environmental aspects.铜代谢缺陷与肝脏疾病：环境因素
J Gastroenterol Hepatol. 2002 Dec;17 Suppl 3:S403-7. doi: 10.1046/j.1440-1746.17.s3.35.x.
4
Copper in infant nutrition: safety of World Health Organization provisional guideline value for copper content of drinking water.
J Pediatr Gastroenterol Nutr. 1998 Mar;26(3):251-7. doi: 10.1097/00005176-199803000-00003.
5
Early introduction of copper-contaminated animal milk feeds as a possible cause of Indian childhood cirrhosis.早期引入受铜污染的动物奶饲料可能是印度儿童肝硬化的一个原因。
Lancet. 1983 Oct 29;2(8357):992-5. doi: 10.1016/s0140-6736(83)90980-7.

铜中毒性巨细胞性肝炎

Giant Cell Hepatitis in Copper Toxicosis.

作者信息

Vij Mukul, Sankaranarayanan Srinivas, Sankaranarayanan Valavanur Subramanian, Manoharan Rakesh, Sundaram Sivanandam

机构信息

Department of Pathology, Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, India.

Pediatric Gastroenterology, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.

出版信息

J Clin Exp Hepatol. 2022 Mar-Apr;12(2):719-720. doi: 10.1016/j.jceh.2021.07.006. Epub 2021 Jul 16.

DOI:10.1016/j.jceh.2021.07.006
PMID:35535071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9077156/
Abstract

Cholestatic jaundice in new born and infants results from biliary obstruction or hepatocellular dysfunction. Biliary atresia (BA) and Idiopathic neonatal hepatitis comprises the major aetiology. Cholestasis due to toxins is rare in infants. Indian childhood cirrhosis (ICC) and ICC like diseases have been described in infants. Herein, authors are describing a case of infantile cholestasis presenting at 4 months of age who was diagnosed to have copper related hepatotoxicosis on liver biopsy. Copper tumblers were used for preparation of formula milk that likely was the source of exogenous copper and the child improved well after removing the source of exogenous copper.

摘要

新生儿和婴儿的胆汁淤积性黄疸是由胆道梗阻或肝细胞功能障碍引起的。胆道闭锁（BA）和特发性新生儿肝炎是主要病因。婴儿因毒素导致的胆汁淤积很少见。婴儿期曾描述过印度儿童肝硬化（ICC）及类似ICC的疾病。在此，作者描述了一例4个月大出现婴儿胆汁淤积的病例，该患儿经肝活检诊断为与铜相关的肝中毒。曾使用铜杯制备配方奶，这可能是外源性铜的来源，去除外源性铜来源后患儿恢复良好。