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专家视角下的血管炎病理表现。

Expert perspectives on pathological findings in vasculitis.

机构信息

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

Division of Dermatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.

出版信息

Mod Rheumatol. 2023 Jan 3;33(1):1-11. doi: 10.1093/mr/roac043.

Abstract

Pathological findings are important in the diagnosis of vasculitis. However, due to the rarity of the disease, standard textbooks usually devote only a few pages to this topic, and this makes it difficult for clinicians not specializing in vasculitis to fully understand the pathological findings in vasculitis. To address the paucity of information, we present representative pathological findings in vasculitis classified in the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides (CHCC2012). The CHCC2012 classifies 26 vasculitides into seven categories: (1) large-vessel vasculitis, (2) medium-vessel vasculitis, (3) small-vessel vasculitis, including antineutrophil cytoplasmic antibody-associated vasculitis and immune complex small-vessel vasculitis, (4) variable-vessel vasculitis, (5) single-organ vasculitis, (6) vasculitis associated with systemic disease, and (7) vasculitis associated with probable aetiology. Moreover, representative pathological findings of vasculitis-related diseases and non-inflammatory vasculopathy not mentioned in the CHCC2012 are also presented. This will be useful for clinicians to refer to typical pathological findings of vasculitis in daily practice.

摘要

病理学发现对血管炎的诊断很重要。然而,由于该病罕见,通常在标准教科书中仅用几页篇幅来讨论这个问题,这使得不专门研究血管炎的临床医生难以充分了解血管炎的病理学发现。为了解决信息不足的问题,我们介绍了 2012 年修订的国际 Chapel Hill 共识会议血管炎命名分类(CHCC2012)中分类的代表性血管炎病理学发现。CHCC2012 将 26 种血管炎分为七类:(1)大血管血管炎,(2)中血管血管炎,(3)小血管血管炎,包括抗中性粒细胞胞质抗体相关性血管炎和免疫复合物性小血管血管炎,(4)多血管炎,(5)单一器官血管炎,(6)与系统性疾病相关的血管炎,(7)与可能病因相关的血管炎。此外,还介绍了 CHCC2012 中未提及的血管炎相关疾病和非炎症性血管病变的代表性病理学发现。这将有助于临床医生在日常实践中参考血管炎的典型病理学发现。

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