Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center/Sophia Children's Hospital, Rotterdam, The Netherlands.
Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark; Clinical-Microbiomics A/S, CØpenhagen East, Denmark.
Clin Nutr. 2022 Jun;41(6):1290-1296. doi: 10.1016/j.clnu.2022.04.015. Epub 2022 Apr 22.
BACKGROUND & OBJECTIVES: Early life is a critical window for adiposity programming and metabolic profile may affect this programming. We investigated if plasma metabolites at age 3 months were associated with fat mass, fat free mass and abdominal subcutaneous and visceral fat outcomes at age 2 years in a cohort of healthy infants and if these associations were different between infants receiving exclusive breastfeeding (EBF) and those with exclusive formula feeding (EFF).
In 318 healthy term-born infants, we determined body composition by Dual Energy X-ray absorptiometry (DXA) and visceral fat by abdominal ultrasound at 2 age years. High-throughput metabolic profiling was performed on blood samples collected at age 3 months. Tertiles were generated for each body composition outcome and differences in plasma metabolite levels at age 3 months between infants with high and low body composition outcomes at age 2 years were evaluated in general, as well as separately in EBF- and EFF-infants.
Distinct plasma metabolite variables identified at age 3 months were associated with body composition at 2 years. These metabolites included several classes of lyso-phospholipids. Associations between the metabolites at age 3 months and fat mass index, fat mass percentage, fat free mass index and visceral fat at 2 years were predominantly found in EBF-infants.
Associations between plasma metabolite levels at age 3 months and high body fat mass at 2 years depend on infant feeding type. These findings contribute to our insight into the importance of infant feeding on adiposity programming in early life.
生命早期是肥胖编程的关键窗口期，代谢特征可能会影响这种编程。我们研究了在一个健康婴儿队列中，3 个月时的血浆代谢物是否与 2 岁时的脂肪量、去脂体重和腹部皮下及内脏脂肪结局有关，以及这些关联在接受纯母乳喂养（EBF）和纯配方奶喂养（EFF）的婴儿之间是否存在差异。
在 318 名健康足月出生的婴儿中，我们在 2 岁时通过双能 X 射线吸收法（DXA）测定体成分，通过腹部超声测定内脏脂肪。在 3 个月时采集血样进行高通量代谢组学分析。为每个体成分结局生成三分位数，并评估在 2 岁时体成分高和低的婴儿在 3 个月时的血浆代谢物水平之间的差异。
在 3 个月时鉴定出的不同血浆代谢物变量与 2 岁时的体成分有关。这些代谢物包括几种溶血磷脂类。在 EBF 婴儿中，3 个月时的代谢物与 2 岁时的体质指数、体脂百分比、去脂体重指数和内脏脂肪之间存在关联。
3 个月时的血浆代谢物水平与 2 岁时高体脂肪量之间的关联取决于婴儿喂养类型。这些发现有助于我们深入了解婴儿喂养对生命早期肥胖编程的重要性。
