Department of Pediatrics, Subdivision of Endocrinology, Erasmus MC/Sophia Children's Hospital, Rotterdam, the Netherlands.
Nutricia Research, Utrecht, the Netherlands.
Ann Nutr Metab. 2017;71(3-4):203-210. doi: 10.1159/000481539. Epub 2017 Nov 14.
Accelerated gain in fat mass in the first months of life is considered to be a risk factor for adult diseases, given the tracking of infancy fat mass into adulthood. Our objective was to assess the influence of early growth, type of feeding and maternal variables on fat mass in early life.
In 300 healthy term infants, we longitudinally measured fat mass percentage (FM%) by air-displacement-plethysmography at 1, 3, and 6 months and abdominal visceral and subcutaneous fat measured by ultrasound at 3 and 6 months.
Both gain in FM% and weight-for-length in the first 3 months were positively associated with FM% at 6 months of age and visceral fat at 3 months of age. Gain in FM% and weight-for-length between 3 and 6 months were both positively associated with visceral fat at 6 months. Breastfeeding duration associated positively with subcutaneous fat but not with visceral fat at 3 and 6 months. Maternal characteristics did not associate with FM% or visceral fat at 3 or 6 months.
Higher gain in FM% or in weight-for-length in the first postnatal months leads not only to higher FM% but also more to accumulation of visceral fat. Exclusive breastfeeding appears to promote subcutaneous but not visceral fat in the first 6 months.
生命最初几个月脂肪量的加速增长被认为是成年疾病的一个风险因素，因为婴儿期的脂肪量会追踪到成年期。我们的目的是评估早期生长、喂养类型和产妇变量对生命早期脂肪量的影响。
在 300 名健康的足月婴儿中，我们通过空气置换体积描记法在 1、3 和 6 个月时进行脂肪量百分比（FM%）的纵向测量，并在 3 和 6 个月时通过超声测量腹部内脏和皮下脂肪。
前 3 个月的 FM%增长和体重-身长增长均与 6 个月时的 FM%和 3 个月时的内脏脂肪呈正相关。3 至 6 个月期间的 FM%增长和体重-身长增长均与 6 个月时的内脏脂肪呈正相关。母乳喂养时间与 3 个月和 6 个月时的皮下脂肪呈正相关，但与内脏脂肪无关。产妇特征与 3 个月或 6 个月时的 FM%或内脏脂肪均无关联。
生命最初几个月 FM%或体重-身长增长较高，不仅会导致 FM%较高，而且还会导致内脏脂肪积累增加。纯母乳喂养在头 6 个月似乎促进了皮下脂肪而不是内脏脂肪的增长。
