Biomedical Instrumentation Laboratory, Institute of Biology and Faculty of Engineering, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Department of Internal Medicine, Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Med Biol Eng Comput. 2022 Jul;60(7):2001-2014. doi: 10.1007/s11517-022-02584-2. Epub 2022 May 10.
To evaluate the ability of tracheal sound analysis (TSA) to detect airflow obstruction, particularly in patients with acromegaly. A simulated analysis compared free airflow conditions with airflow through orifice plates 6, 8, 10 and 12 mm in diameter. Based on these results, TSA and spirometry examinations were performed on controls (n = 17) and patients with acromegaly (n = 17). The simulated study showed that airway obstruction and airflow values increased the values of power and a progressive displacement of the spectral distribution towards higher frequencies. In agreement with the simulation, airway obstruction in patients with acromegaly also resulted in increased values of power (p < 0.002) and displacement of the spectral distribution (p < 0.01). Significant associations were observed between the TSA parameters and the spirometry indices of obstruction (p < 0.02). In addition, the TSA parameters achieved adequate diagnostic accuracy (AUC ≥ 0.887). The present study provides evidence that TSA during resting breathing would provide adequate biomarkers of early upper airway changes in patients with acromegaly. TSA is carried out during spontaneous ventilation, requires little from the patient, and is fast and inexpensive. Taken together, these practical considerations and the results of the present study suggest that TSA may improve lung function tests for patients with acromegaly. Summary of the study, overall design flow and the main results obtained.
评估气管音分析（TSA）检测气流阻塞的能力，特别是在肢端肥大症患者中。模拟分析比较了自由气流条件和通过直径为 6、8、10 和 12 毫米的孔板的气流。基于这些结果，对对照组（n=17）和肢端肥大症患者（n=17）进行了 TSA 和肺功能检查。模拟研究表明气道阻塞和气流值增加了功率值，并使频谱分布向更高频率逐渐移位。与模拟结果一致，肢端肥大症患者的气道阻塞也导致功率值增加（p<0.002）和频谱分布的移位（p<0.01）。TSA 参数与阻塞性肺功能指标之间存在显著相关性（p<0.02）。此外，TSA 参数具有足够的诊断准确性（AUC≥0.887）。本研究提供了证据表明，在休息呼吸期间进行 TSA 将为肢端肥大症患者的上呼吸道早期变化提供足够的生物标志物。TSA 在自主通气期间进行，对患者的要求不高，快速且经济实惠。综上所述，这些实际考虑因素和本研究的结果表明，TSA 可能会改善肢端肥大症患者的肺功能检查。研究总结、总体设计流程和获得的主要结果。
