Institute of Biomedical Sciences, Universidade Federal de Alfenas, Alfenas, Minas Gerais, Brazil.
Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Tochigi, Japan.
PeerJ. 2022 May 5;10:e13401. doi: 10.7717/peerj.13401. eCollection 2022.
Hosts and their microbiota and parasites have co-evolved in an adaptative relationship since ancient times. The interaction between parasites and intestinal bacteria in terms of the hosts' health is currently a subject of great research interest. Therapeutic interventions can include manipulations of the structure of the intestinal microbiota, which have immunological interactions important for modulating the host's immune system and for reducing inflammation. Most helminths are intestinal parasites; the intestinal environment provides complex interactions with other microorganisms in which internal and external factors can influence the composition of the intestinal microbiota. Moreover, helminths and intestinal microorganisms can modulate the host's immune system either beneficially or harmfully. The immune response can be reduced due to co-infection, and bacteria from the intestinal microbiota can translocate to other organs. In this way, the treatment can be compromised, which, together with drug resistance by the parasites makes healing even more difficult. Thus, this work aimed to understand interactions between the microbiota and parasitic diseases caused by the most important geohelminths and schistosomiasis and the consequences of these associations.
自古以来，宿主与其微生物群和寄生虫就一直处于共同进化的适应关系中。目前，寄生虫与肠道细菌之间的相互作用是一个非常有研究兴趣的课题。治疗干预措施可以包括对肠道微生物群结构的操纵，这些操纵具有重要的免疫相互作用，可以调节宿主的免疫系统并减轻炎症。大多数寄生虫是肠道寄生虫；肠道环境与其他微生物之间存在复杂的相互作用，其中内部和外部因素可以影响肠道微生物群的组成。此外，寄生虫和肠道微生物可以对宿主的免疫系统产生有益或有害的影响。由于合并感染，免疫反应可能会减弱，肠道微生物群的细菌也可能转移到其他器官。这样，治疗就会受到影响，再加上寄生虫的耐药性，使治愈更加困难。因此，这项工作旨在了解最重要的土源性线虫和血吸虫病引起的寄生虫病与肠道微生物群之间的相互作用，以及这些关联的后果。
