撤稿文章：白杨素通过抑制心肌炎症减轻心肌缺血再灌注损伤。

Retracted Article: Chrysin attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial inflammation.

作者信息

Wu Jingguo, Xun Nan, Yang Yang, Zeng Lijin, Li Zhenyu, Yang Wen, Liang Yanbing, Tang Hao, Ma Zhongfu

机构信息

Department of General Internal Medicine, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080 People's Republic of China

Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080 People's Republic of China.

出版信息

RSC Adv. 2018 Apr 12;8(25):13739-13746. doi: 10.1039/c8ra00590g. eCollection 2018 Apr 11.

The aim of this study was to investigate the effects of chrysin (CH) on myocardial ischemia-reperfusion injury. Cytokines were reduced by CH in coronary artery occlusion-induced rats and also in H9C2 cells. The ST segment was also restored by CH. Triphenyltetrazolium chloride (TTC) staining and pathological analysis showed that CH could alleviate myocardial injury. Results in H9C2 cells showed that CH improved heart injury in hypoxia/reoxygenation (H/R) of H9C2 cells. In addition, the expressions of the HMGB1-related inflammation pathway in rats and H9C2 cells were significantly decreased by CH. The present study shows the protective effects of CH on myocardial injury inflammation.