Pan Boyu, Ren Yuanyuan, Liu Liren
Department of Gastrointestinal Cancer Biology, Tianjin Medical University Cancer Institute & Hospital Tianjin 300060 China
National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer Tianjin 300060 China.
RSC Adv. 2018 May 23;8(34):18851-18858. doi: 10.1039/c8ra03124j. eCollection 2018 May 22.
Polydatin (PD), a small natural compound originally extracted from , exerts distinct biological functions in a variety of diseases. However, the action mechanism of PD has yet to be systematically explored. In this study, we firstly corroborated the druggability of PD by evaluating the medicinal properties of PD using a TCMSP server. We then conducted target-prediction for PD using PharmMapper and ChemMapper, which led to the identification of 15 potential targets overlapping in both approaches. These 15 targets were subsequently evaluated by GeneMANIA, GO biological process and KEGG pathway analysis, which finally contribute to the construction of a drug-target-pathway network for PD. The network analysis revealed that these targets were mainly associated with cancer, cell growth and apoptosis, hormones and other physiological processes, outlining the pharmacological influences of PD on multiple integrated pathways involved in a particular network.
虎杖苷（PD）是一种最初从……中提取的天然小分子化合物，在多种疾病中发挥着独特的生物学功能。然而，PD的作用机制尚未得到系统研究。在本研究中，我们首先通过使用中药系统药理学数据库与分析平台（TCMSP）服务器评估PD的药用特性，证实了PD的成药性。然后，我们使用PharmMapper和ChemMapper对PD进行靶点预测，结果在两种方法中均鉴定出15个潜在靶点。随后，通过基因共表达网络分析工具（GeneMANIA）、基因本体论（GO）生物学过程分析和京都基因与基因组百科全书（KEGG）通路分析对这15个靶点进行评估，最终构建了PD的药物-靶点-通路网络。网络分析表明，这些靶点主要与癌症、细胞生长和凋亡、激素及其他生理过程相关，勾勒出了PD对特定网络中多个整合通路的药理影响。
