用于CT/MRI成像引导的近红外二区激光响应光热癌症治疗的氮氧化物自由基修饰硫化铜纳米颗粒
Nitroxide radical-modified CuS nanoparticles for CT/MRI imaging-guided NIR-II laser responsive photothermal cancer therapy.
作者信息
Xia Chengwan, Xie Diya, Xiong Lang, Zhang Qian, Wang Yang, Wang Zezheng, Wang Yuxin, Li Bin, Zhang Chao
机构信息
Nanjing Stomatological Hospital, Medical School of Nanjing University Nanjing Jiangsu 210093 P. R. China
Collaborative Innovation Center of Chemistry for Life Sciences, College of Engineering and Applied Sciences, Nanjing University Nanjing Jiangsu 210093 China.
出版信息
RSC Adv. 2018 Jul 31;8(48):27382-27389. doi: 10.1039/c8ra04501a. eCollection 2018 Jul 30.
Herein, we reported nitroxide radical-modified CuS nanoparticles (CuS-NO˙ NPs), and they exhibited a typical absorption peak at 1182 nm. Due to such a long wavelength absorbance, CuS-NO˙ NPs exhibited excellent therapeutic outcome and low damage to normal tissues. Besides, we simultaneously achieved CuS-NO˙ NPs for MRI and CT dual-modal imaging, which successfully provided a new strategy for imaging-guided tumor treatment, thus increasing potential clinical applications for cancer treatment.
在此，我们报道了氮氧自由基修饰的硫化铜纳米颗粒（CuS-NO˙ NPs），它们在1182 nm处呈现出典型的吸收峰。由于这种长波长吸收，CuS-NO˙ NPs表现出优异的治疗效果且对正常组织损伤较小。此外，我们同时实现了CuS-NO˙ NPs用于磁共振成像（MRI）和计算机断层扫描（CT）双模态成像，成功为成像引导的肿瘤治疗提供了一种新策略，从而增加了癌症治疗的潜在临床应用。
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