Chen Anqi, He Huacheng, Ma Guanglong, Li Yi, Jiang Shishuang, Xuan Xuan, Song Yi, Zhang Cuiyun, Xiao Jian, Xu Yunsheng, Wu Jiang, Chen Shengfu
The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 P. R. China
Wenzhou Medical University Wenzhou 325035 P. R. China
RSC Adv. 2018 Mar 16;8(19):10620-10626. doi: 10.1039/c8ra00401c. eCollection 2018 Mar 13.
Hydrogels are one of the most promising wound dressings. However, their effectiveness on wound healing is still largely limited due to either the non-degradability or the release of non-therapeutic degradable products. Herein, a biodegradable copolypeptide hydrogel based on the glutamic acid and lysine was synthesized and applied as both wound dressing and therapeutic prodrug. The hydrogel can degrade in the existence of elevated degradative enzymes in a wound environment, which will release therapeutic amino acids to enhance the wound healing. results found that the hydrogel could effectively promote wound regeneration in both macroscopic and microscopic scales. Further investigation revealed that the wound healing effect of the hydrogel was highly attributed to its enhanced impact on angiogenesis, cell proliferation and re-epithelialization of the wound. All in all, the present study proves that the degradable copolypeptide hydrogel can efficiently improve wound healing and indicates its potent clinical application for wound regeneration.
水凝胶是最具前景的伤口敷料之一。然而，由于其不可降解性或释放非治疗性可降解产物，它们对伤口愈合的有效性在很大程度上仍受到限制。在此，合成了一种基于谷氨酸和赖氨酸的可生物降解共聚多肽水凝胶，并将其用作伤口敷料和治疗性前药。该水凝胶可在伤口环境中降解酶水平升高的情况下发生降解，从而释放治疗性氨基酸以促进伤口愈合。结果发现，该水凝胶能够在宏观和微观尺度上有效促进伤口再生。进一步研究表明，水凝胶的伤口愈合效果高度归因于其对伤口血管生成、细胞增殖和再上皮化的增强作用。总而言之，本研究证明可降解共聚多肽水凝胶能够有效改善伤口愈合，并表明其在伤口再生方面具有强大的临床应用潜力。
