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负载近红外染料的硫化铜-脱铁铁蛋白用于肿瘤成像和光热治疗。

Near infrared dye loaded copper sulfide-apoferritin for tumor imaging and photothermal therapy.

作者信息

He Yuanyuan, Shen Yuanzhi, Zhou Siqi, Wu Yihui, Yuan Zhenwei, Wei Chen, Gui Lijuan, Chen Yisha, Gu Yueqing, Chen Haiyan

机构信息

Department of Biomedical Engineering, School of Engineering, State Key Laboratory of Natural Medicines, China Pharmaceutical University 24 Tongjia Lane, Gulou District Nanjing 210009 China

JSerra Catholic High School 26351 Junipero Serra Road San Juan Capistrano CA 92675.

出版信息

RSC Adv. 2018 Apr 17;8(26):14268-14279. doi: 10.1039/c8ra00911b.

DOI:10.1039/c8ra00911b
PMID:35540767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9079858/
Abstract

Development of photothermal agents for imaging-guided photothermal therapy (PTT) has been of great interest in the field of nanomedicine. CuS-apoferritin was prepared by a biomimetic synthesis method by using the inside cavity of apoferritin to control the size of CuS nanoparticles. Then, a water-soluble near infrared (NIR) dye (MBA) was bound with CuS-apoferritin, forming a nanocomplex (CuS-apoferritin-MBA) with greatly enhanced photothermal conversion efficiency compared to CuS-apoferritin. The unique optical behavior of CuS-apoferritin-MBA enables fluorescence imaging and photothermal therapy at separated optical wavelengths both, with optimized performances. CuS-apoferritin-MBA was then utilized as a photothermal agent for imaging-guided photothermal therapy in tumor-bearing mouse models. As revealed by fluorescence imaging, CuS-apoferritin-MBA showed high tumor uptake owing to an enhanced permeability and retention effect and the active targeting of apoferritin. photothermal therapy experiments indicated that tumors could be ablated by combining CuS-apoferritin-MBA with irradiation of an 808 nm laser. Thus, our work presents a safe, simple photothermal nanocomplex, promising for future clinical translation in cancer treatment.

摘要

用于成像引导光热疗法（PTT）的光热剂的开发在纳米医学领域引起了极大的关注。通过仿生合成方法，利用脱铁铁蛋白的内腔来控制硫化铜纳米颗粒的尺寸，制备了硫化铜-脱铁铁蛋白。然后，将一种水溶性近红外（NIR）染料（MBA）与硫化铜-脱铁铁蛋白结合，形成一种纳米复合物（硫化铜-脱铁铁蛋白-MBA），与硫化铜-脱铁铁蛋白相比，其光热转换效率大大提高。硫化铜-脱铁铁蛋白-MBA独特的光学行为使其能够在分离的光学波长下进行荧光成像和光热疗法，且性能优化。随后，硫化铜-脱铁铁蛋白-MBA被用作荷瘤小鼠模型中成像引导光热疗法的光热剂。荧光成像显示，由于增强的渗透和滞留效应以及脱铁铁蛋白的主动靶向作用，硫化铜-脱铁铁蛋白-MBA在肿瘤中具有高摄取。光热疗法实验表明，将硫化铜-脱铁铁蛋白-MBA与808nm激光照射相结合可消融肿瘤。因此，我们的工作展示了一种安全、简单的光热纳米复合物，有望在未来癌症治疗的临床转化中发挥作用。

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