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整合代谢组学和转录组学分析揭示了麦冬适应干旱过程中黄酮类化合物合成的差异表达。

Integrative metabolomics and transcriptomics profiling reveals differential expression of flavonoid synthesis in Ophiopogon japonicus (L. f.) Ker-Gawl. in adaptation to drought.

作者信息

Cheng Tingting, Lin Juan, Zhou Xia, Wang Hongsu, Zhou Xianjian, Huang Xiaopeng, Chen Tiezhu

机构信息

Sichuan Academy of Chinese Medicine Sciences, Chengdu, China.

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

出版信息

PLoS One. 2025 Jan 7;20(1):e0313580. doi: 10.1371/journal.pone.0313580. eCollection 2025.

DOI:10.1371/journal.pone.0313580
PMID:39774546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11706389/
Abstract

Drought is one of the consequences of climate change that severely affects plant growth and development. Ophiopogon japonicus (L. f.) Ker-Gawl. (Chinese name: Chuanmaidong, abbreviated as CMD) is a commonly used herbaceous plant whose growth and development are strongly affected by drought. Here, we comprehensively analyzed the transcriptomic and metabolic responses of two CMD varieties (EP and CP) to drought stress. CP utilized a small number of differentially expressed genes to regulate a greater number of differential metabolites compared to EP, suggesting that it may be more drought tolerant. In addition, integrated transcriptome and metabolome analyses revealed that transcription factors such as WRKY, TIFY, and C2H2 regulate flavonoid synthesis in CMD. These findings provide ideas for in-depth analysis of the mechanism of CMD against drought stress, and provide a theoretical basis for breeding high-quality drought-tolerant varieties.

摘要

干旱是气候变化的后果之一，严重影响植物的生长发育。麦冬（学名：Ophiopogon japonicus (L. f.) Ker-Gawl.，中文名：川麦冬，简称CMD）是一种常用的草本植物，其生长发育受到干旱的强烈影响。在此，我们全面分析了两个CMD品种（EP和CP）对干旱胁迫的转录组和代谢反应。与EP相比，CP利用少量差异表达基因调控了更多的差异代谢物，这表明它可能更耐旱。此外，转录组和代谢组的综合分析表明，WRKY、TIFY和C2H2等转录因子调控CMD中的类黄酮合成。这些发现为深入分析CMD抗旱胁迫机制提供了思路，并为培育优质耐旱品种提供了理论依据。

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