Jun Yong Woong, Sarkar Sourav, Singha Subhankar, Reo Ye Jin, Kim Hye Rim, Kim Jong-Jin, Chang Young-Tae, Ahn Kyo Han
Department of Chemistry, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyungbuk 37673, Republic of Korea.
Chem Commun (Camb). 2017 Sep 28;53(78):10800-10803. doi: 10.1039/c7cc05834a.
A fluorescent probe that enables ratiometric imaging of endogenous hypochlorous acid (HOCl) in cells and tissues by two-photon microscopy is developed based on a red-emitting acetyl-benzocoumarin (AcBC) dye. An oxathiolane group in the probe reacts with HOCl to generate the AcBC dye, which involves a ratiometric fluorescence change only toward HOCl along with high sensitivity.
基于一种发红光的乙酰苯并香豆素（AcBC）染料，开发了一种荧光探针，该探针能够通过双光子显微镜对细胞和组织中的内源性次氯酸（HOCl）进行比率成像。探针中的氧硫杂环戊烷基团与HOCl反应生成AcBC染料，该反应仅对HOCl产生比率荧光变化，且灵敏度高。
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