Gelat Fabien, Roger Maxime, Penverne Christophe, Mazzad Ahmed, Rolando Christian, Chausset-Boissarie Laëtitia
USR 3290, MSAP, Miniaturisation pour la Synthèse l'Analyse et la Protéomique and FR 2638, Institut Eugène-Michel Chevreul, Université de Lille F-59000 Lille France
RSC Adv. 2018 Feb 23;8(15):8385-8392. doi: 10.1039/c7ra12977g. eCollection 2018 Feb 19.
A UV-mediated hydrophosphinylation of unactivated alkenes with -phosphinates and hypophosphorous acid under radical free conditions is presented. The reaction affords selectively a large number of structurally diverse organophosphorous compounds in moderate to good yields under mild reaction conditions in the presence of an organic sensitizer as catalyst irradiated by UV-A LEDs. Furthermore, the high yielding hydrophosphinylation in continuous flow is disclosed.
本文报道了在无自由基条件下，未活化烯烃与次膦酸酯和次磷酸的紫外介导氢膦酰化反应。在有机敏化剂作为催化剂且由UV-A发光二极管照射的条件下，该反应在温和的反应条件下以中等至良好的产率选择性地提供了大量结构多样的有机磷化合物。此外，还公开了连续流中的高产率氢膦酰化反应。
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