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高度水分散性的木质素磺酸钙包覆的MnO纳米颗粒作为一种具有出色胶体稳定性、低毒性和显著弛豫率的MRI造影剂。

Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity.

作者信息

Arian Mahdi, Zamanian Ali, Taheri Salman

机构信息

Biomaterials Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC) PO Box 14155-4777 Tehran Iran

Chemistry and Chemical Engineering Research Center of Iran (CCERCI) PO Box 14335-186 Tehran Iran

出版信息

RSC Adv. 2019 Dec 6;9(69):40498-40506. doi: 10.1039/c9ra09125d. eCollection 2019 Dec 3.

DOI:10.1039/c9ra09125d
PMID:35542658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9076238/
Abstract

A simple and efficient method to synthesize highly water-dispersible calcium lignosulfonate-coated manganese oxide nanoparticles as a potential candidate for the current magnetic resonance imaging (MRI) contrast agents was reported. Hydrophobic MnO nanoparticles with dimensions of about 10 nm were prepared by thermal decomposition of manganese(ii)acetylacetonate in the presence of oleic acid as a surfactant. The characteristics of the synthesized nanoparticles, cytotoxicity assay and MRI properties were investigated in detail. Results showed that calcium lignosulfonate has a great influence on the colloidal stability and biocompatibility of MnO nanoparticles in water. Furthermore, this coating agent ensures abundant exposure of external Mn ion with protons of water, which endows the nanoparticles with a longitudinal molar relaxivity ( ) of 4.62 mM s. An efficient contrast enhancement effect was observed in the study of MRI investigations.

摘要

报道了一种简单有效的方法来合成高度水分散性的木质素磺酸钙包覆的氧化锰纳米颗粒，作为当前磁共振成像（MRI）造影剂的潜在候选物。通过在油酸作为表面活性剂存在下热分解乙酰丙酮锰（II）制备了尺寸约为10nm的疏水性MnO纳米颗粒。详细研究了合成纳米颗粒的特性、细胞毒性测定和MRI性质。结果表明，木质素磺酸钙对MnO纳米颗粒在水中的胶体稳定性和生物相容性有很大影响。此外，这种包覆剂确保外部Mn离子与水质子大量接触，赋予纳米颗粒4.62 mM s的纵向摩尔弛豫率（ ）。在MRI研究中观察到了有效的造影增强效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7200/9076238/1e973bad24e3/c9ra09125d-f7.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7200/9076238/c7643d193d36/c9ra09125d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7200/9076238/1e973bad24e3/c9ra09125d-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7200/9076238/a2425761d68a/c9ra09125d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7200/9076238/287e7bb48173/c9ra09125d-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7200/9076238/d416f64613ab/c9ra09125d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7200/9076238/25fcca3ae7ed/c9ra09125d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7200/9076238/c7643d193d36/c9ra09125d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7200/9076238/1e973bad24e3/c9ra09125d-f7.jpg

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