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钌配合物催化的内炔烃的区域选择性和立体选择性硅氢化反应

Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes.

作者信息

Dai Wenhao, Wu Xiaowei, Li Chunpu, Zhang Rui, Wang Jiang, Liu Hong

机构信息

School of Pharmacy, China Pharmaceutical University Nanjing 210009 Jiangsu China.

Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 555 Zu Chong Zhi Road Shanghai 201203 China

出版信息

RSC Adv. 2018 Aug 7;8(49):28261-28265. doi: 10.1039/c8ra04083d. eCollection 2018 Aug 2.

DOI:10.1039/c8ra04083d
PMID:35542735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9084253/
Abstract

In this study, ruthenium(ii)-catalyzed direct hydrosilylation of internal alkynes with high regio-selectivity and stereo-selectivity is reported. This title transformation led to various vinylsilanes in good to excellent yields. This approach features mild reaction conditions, low catalyst loading, air-stability, and good functional group tolerance. Furthermore, gram-scale preparation and some transformations of vinylsilanes were carried out, which further underscored its synthetic utility and applicability.

摘要

本研究报道了钌（II）催化的内炔烃直接硅氢化反应，该反应具有高区域选择性和立体选择性。此反应可得到各种乙烯基硅烷，产率良好至优异。该方法具有反应条件温和、催化剂负载量低、空气稳定性好以及对官能团耐受性良好等特点。此外，还进行了乙烯基硅烷的克级制备及一些转化反应，进一步突出了其合成实用性和适用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c75a/9084253/5f97c10cf3d0/c8ra04083d-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c75a/9084253/2e685020d748/c8ra04083d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c75a/9084253/bcfe677d7542/c8ra04083d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c75a/9084253/4be689c29c4c/c8ra04083d-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c75a/9084253/5f97c10cf3d0/c8ra04083d-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c75a/9084253/2e685020d748/c8ra04083d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c75a/9084253/bcfe677d7542/c8ra04083d-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c75a/9084253/4be689c29c4c/c8ra04083d-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c75a/9084253/5f97c10cf3d0/c8ra04083d-s3.jpg

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Cobalt-Catalyzed Z-Selective Hydrosilylation of Terminal Alkynes.钴催化的末端炔烃 Z-选择性硅氢化反应。
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Ruthenium-Catalyzed Alkyne trans-Hydrometalation: Mechanistic Insights and Preparative Implications.
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Borane-Catalyzed Selective Hydrosilylation of Internal Ynamides Leading to β-Silyl (Z)-Enamides.硼烷催化内炔酰胺的选择性硅氢化反应生成β-硅基（Z）-烯酰胺。
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Copper-Catalyzed Oxidative ipso-Annulation of Activated Alkynes with Silanes: An Approach to 3-Silyl Azaspiro[4,5]trienones.铜催化的硅烷与炔烃的氧化 ipso-环化反应：一种合成 3-硅基氮杂螺[4.5]癸-5-酮的方法。
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