Department of Biosciences, Jamia Millia Islamia (A central University), Jamia Nagar, 110025, New Delhi, India.
Amity Stem Cell Institute/Amity Medical School, Amity University Haryana, Amity Education Valley, Panchgaon (Manesar), Gurugram, HR, 122413, India.
Mol Biol Rep. 2022 Aug;49(8):8087-8107. doi: 10.1007/s11033-022-07357-6. Epub 2022 May 11.
The microbiota has been associated with different cancer and may vary from patient to patient. A specific microbial strain can alter the progression of cancer and therapeutic outcome in response to anti-cancer therapy. The variations in microbiota contributed due to the individual microbiome of the microorganism are responsible for diverse clinical outcomes. The expansion of microbiota subpopulation during dysbiosis can lead to toxin production, inducing inflammation and cancer. The microbiota can be a dual-edged sword because it can be tumor-suppressive or oncogenic in the case of the gut. The transition of cancer cells from early to late-stage also impacts the composition of the microbiota, and this alteration could change the behavior of cancer. Multi-omics platforms derived data from an individual's multi-dimensional data (DNA, mRNA, microRNA, protein, metabolite, microbiota, and microbiome), i.e., individualome, to exploit it for personalized tailored treatment for different cancers in a precise manner. A number of studies suggest the importance of microbiota and its add-in suitability to existing treatment options for different malignancies. Furthermore, in vitro, and in vivo studies and cancer clinical trials suggest that probiotics have driven modulation of gut microbiota and other sites discourage the aggressive behavior and progression of different cancers.
微生物组与不同的癌症有关，并且可能因患者而异。特定的微生物菌株可以改变癌症的进展和对癌症治疗的反应。由于微生物个体微生物组的不同，微生物组的变化导致了不同的临床结果。在生态失调期间，微生物种群的扩张会导致毒素的产生，从而引发炎症和癌症。微生物组可以是一把双刃剑，因为它在肠道中既可以抑制肿瘤，也可以致癌。癌细胞从早期到晚期的转变也会影响微生物组的组成，这种改变可能会改变癌症的行为。多组学平台从个体的多维数据（DNA、mRNA、microRNA、蛋白质、代谢物、微生物组和微生物组）中获取数据，即个体组学，以精确地利用它为不同癌症提供个性化的治疗方案。许多研究表明了微生物组的重要性及其对现有治疗方案的补充适用于不同的恶性肿瘤。此外，体外和体内研究以及癌症临床试验表明，益生菌可以调节肠道微生物组和其他部位，抑制不同癌症的侵袭性行为和进展。
