Department of Infectious disease, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, No. 60 Jingzhong Road, Jingzhou District, Jingzhou, 434020, Hubei Province, China.
Laboratory of Oncology, Center for Molecular Medicine, School of Basic Medicine, Health Science Center, Yangtze University, 1 Nanhuan Road, Jingzhou, 434023, Hubei, China.
Invest New Drugs. 2021 Jun;39(3):871-878. doi: 10.1007/s10637-021-01063-z. Epub 2021 Jan 17.
Breast cancer is the most diagnosed cancer in women. It significantly impairs a patient's physical and mental health. Gut microbiota comprise the bacteria residing in a host's gastrointestinal tract. Through studies over the last decade, we now know that alterations in the composition of the gut microbiome are associated with protection against colonization by pathogens and other diseases, such as diabetes and cancer. This review focuses on how gut microbiota can affect breast cancer development through estrogen activity and discusses the types of bacteria that may be involved in the onset and the progression of breast cancer. We also describe potential therapies to curtail the risk of breast cancer by restoring gut microbiota homeostasis and reducing systemic estrogen levels. This review will further explore the relationship between intestinal microbes and breast cancer and propose a method to treat breast cancer by improving intestinal microbes. We aimed at discovering new methods to prevent or treat BC by changing intestinal microorganisms.
乳腺癌是女性最常见的癌症。它严重损害了患者的身心健康。肠道微生物组由存在于宿主胃肠道内的细菌组成。通过过去十年的研究，我们现在知道，肠道微生物组组成的改变与防止病原体定植和其他疾病（如糖尿病和癌症）有关。本综述重点讨论了肠道微生物群如何通过雌激素活性影响乳腺癌的发展，并讨论了可能参与乳腺癌发生和进展的细菌类型。我们还描述了通过恢复肠道微生物群平衡和降低全身雌激素水平来降低乳腺癌风险的潜在治疗方法。本综述将进一步探讨肠道微生物与乳腺癌之间的关系，并提出通过改善肠道微生物来治疗乳腺癌的方法。我们旨在通过改变肠道微生物来发现预防或治疗乳腺癌的新方法。
