Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, 06100, Tandoğan-Ankara, Turkey.
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria.
Chem Biodivers. 2022 Sep;19(9):e202200167. doi: 10.1002/cbdv.202200167. Epub 2022 Aug 31.
Anomalin is a seselin-type pyranocoumarin isolated for the first time from Angelica anomala Avé-Lal, but is also found in several other plant species, especially in Apiaceae. This lipophilic molecule possesses pharmacologically beneficial activities for human health. The major scientific databases Scopus, Web of Science, Google Scholar, and PubMed up to the end of 2021 and the combining terms anomalin, praeruptorin, isolation, structure elucidation, and biological activity were used in the research of this review. This review focuses on the sources, structural properties, and biological functions of anomalin and provides future trends in the investigation of anomalin, particularly in therapies for many common diseases such as anti-inflammatory and neurodegenerative illnesses. As a potential bioactive molecule, prospective studies on anomalin should be done through supported clinical trials. At the end, this review confirms the significant pharmacological potential of anomalin.
山芹素是一种从独活属植物（Angelica anomala Avé-Lal）中首次分离得到的Seselin 型吡喃香豆素，但也存在于其他几种植物中，特别是伞形科植物中。这种亲脂性分子对人类健康具有有益的药理活性。截至 2021 年底，主要的科学数据库 Scopus、Web of Science、Google Scholar 和 PubMed 以及组合词 anomalin、praeruptorin、isolation、structure elucidation 和 biological activity 都被用于本综述的研究。本综述重点介绍了山芹素的来源、结构特性和生物学功能，并提供了山芹素研究的未来趋势，特别是在治疗许多常见疾病（如抗炎和神经退行性疾病）方面的研究趋势。作为一种有潜力的生物活性分子，应对山芹素进行有支持的临床试验的前瞻性研究。最后，本综述证实了山芹素具有显著的药理学潜力。
