Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris (UPSI), Tanjung Malim, Perak, Malaysia.
Department of Pharmacognosy, College of Pharmacy, Kerbala University, Kerbala, Iraq.
J Pharm Pharmacol. 2021 Mar 1;73(1):1-21. doi: 10.1093/jpp/rgaa034.
The genus Ferulago belonging to the family Apiaceae is a flora widely distributed in Central Asia and the Mediterranean and used in folk medicine. It is administered as a sedative, tonic, digestive, aphrodisiac, also as a treatment for intestinal worms and haemorrhoids. Herein, we reported a review on phytochemistry and its biological activities reported from 1990 up to early 2020. All the information and reported studies concerning Ferulago plants were summarized from the library and digital databases (e.g. Scopus, Medline, Scielo, ScienceDirect, SciFinder and Google Scholar).
The phytochemical investigations of Ferulago species revealed the presence of coumarins as the main bioactive compounds, including daucane derivatives, sesquiterpenes aryl esters, phenol derivatives, flavonoids and essential oils. Moreover, the therapeutic potentials of the pure compounds isolated from the genus Ferulago possess promising properties namely anticholinesterase, antimicrobial, anticoagulant, antileishmanial, antioxidant, antibacterial and antiproliferative.
Today, significant advances in phytochemical and biological activity studies of different Ferulago species have been revealed. The traditional uses and reported biological results could be correlated via the chemical characterization of these plants. All these data will support the biologists in the elucidation of the biological mechanisms of these plants.
Ferulago 属属于伞形科，广泛分布于中亚和地中海地区的植物群，在民间医学中被用作镇静剂、滋补剂、消化剂、壮阳药，也用于治疗肠道蠕虫和痔疮。本文综述了 1990 年至 2020 年初报道的该属植物的植物化学和生物活性。从图书馆和数字数据库（例如 Scopus、Medline、Scielo、ScienceDirect、SciFinder 和 Google Scholar）中汇总了有关 Ferulago 植物的所有信息和报道的研究。
Ferulago 物种的植物化学研究表明，香豆素是主要的生物活性化合物，包括达烷衍生物、倍半萜芳基酯、酚类衍生物、类黄酮和精油。此外，从 Ferulago 属中分离得到的纯化合物具有抗胆碱酯酶、抗菌、抗凝、抗利什曼原虫、抗氧化、抗菌和抗增殖等有前途的特性。
如今，不同 Ferulago 物种的植物化学和生物活性研究取得了重大进展。传统用途和报道的生物学结果可以通过这些植物的化学特征来关联。所有这些数据将支持生物学家阐明这些植物的生物学机制。
