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利用 SERS 研究人血小板的光谱均一性。

Spectral homogeneity of human platelets investigated by SERS.

机构信息

REC «Fundamental and Applied Photonics, Nanophotonics», Immanuel Kant Baltic Federal University, Kaliningrad, Kaliningrad Region, Russia.

REC «Clinical Trials Center», Immanuel Kant Baltic Federal University, Kaliningrad, Kaliningrad Region, Russia.

出版信息

PLoS One. 2022 May 11;17(5):e0265247. doi: 10.1371/journal.pone.0265247. eCollection 2022.

DOI:10.1371/journal.pone.0265247
PMID:35544536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9094501/
Abstract

This paper describes a detailed study of the spectral homogeneity of human platelets using Surface-enhanced Raman spectroscopy (SERS). We used a combined approach based on multivariate methods as principal component analysis and pair correlation algorithms to investigate platelets spectral properties. The correlation coefficients for each sample have been calculated, and the average coefficient of determination has been estimated. The high degree of spectral homogeneity inside one probe and between them has been revealed. The prospects of obtained results usage for pathologies based on platelet conformations during cardiovascular diseases have been demonstrated.

摘要

本文使用表面增强拉曼光谱（SERS）详细研究了人类血小板的光谱均一性。我们采用了一种基于多元方法的组合方法，如主成分分析和对关联算法，来研究血小板的光谱特性。计算了每个样本的相关系数，并估计了平均确定系数。揭示了一个探头内和探头之间的高度光谱均一性。展示了基于心血管疾病期间血小板构象的病理学中获得的结果的应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10aa/9094501/dfc890c9702b/pone.0265247.g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10aa/9094501/422959352bd5/pone.0265247.g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10aa/9094501/551242bf8924/pone.0265247.g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10aa/9094501/dfc890c9702b/pone.0265247.g008.jpg

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