Shaanxi Key Laboratory of Behavior and Cognitive Neuroscience, School of Psychology, Shaanxi Normal University, Xi'an, China.
School of Education, Qinghai Normal University, Xining, China.
Psychiatry Res. 2022 Jul;313:114598. doi: 10.1016/j.psychres.2022.114598. Epub 2022 May 8.
Depression is the leading cause of physiological problems and suicide. Previous studies have indicated that individuals with depression show abnormal processing of both positive and negative emotional stimuli. However, the common and distinct patterns of brain activity during the processing of positive and negative emotional stimuli in individuals with depression remain controversial. The current meta-analysis study used the activation likelihood estimation method to investigate these issues across 21 functional magnetic resonance imaging studies. Results revealed that, compared with individuals without depression, individuals with depression showed higher activation in the anterior cingulate gyrus, insula, and middle frontal gyrus (MFG) for positive emotional stimuli and higher activation in the MFG, inferior frontal gyrus, and insula for negative emotional stimuli. Moreover, we identified that the MFG was consistently activated in individuals with depression regardless of the type of emotional stimuli. However, we did not find distinct patterns of brain activity between positive and negative emotional stimuli in individuals with depression. Our results demonstrated that both positive and negative emotional stimuli processing shares the same cognitive control-related brain regions in individuals with depression.
抑郁症是生理问题和自杀的主要原因。先前的研究表明，抑郁症患者在处理正负情绪刺激时表现出异常的加工方式。然而，抑郁症患者在处理正负情绪刺激时大脑活动的共同和独特模式仍存在争议。本元分析研究使用激活似然估计法，对 21 项功能磁共振成像研究进行了研究。结果表明，与无抑郁个体相比，抑郁个体在处理正性情绪刺激时，前扣带回、岛叶和额中回（MFG）的激活度更高，在处理负性情绪刺激时，MFG、额下回和岛叶的激活度更高。此外，我们发现，无论情绪刺激的类型如何，MFG 在抑郁个体中始终处于激活状态。然而，我们并未发现抑郁个体中正负情绪刺激之间存在明显的大脑活动模式差异。我们的研究结果表明，正性和负性情绪刺激的处理在抑郁症患者中共享相同的与认知控制相关的大脑区域。
