Department of Child and Adolescent Psychiatry, Copenhagen University Hospital - Psychiatry Region Zealand, Roskilde, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Autism Res. 2022 Aug;15(8):1469-1481. doi: 10.1002/aur.2738. Epub 2022 May 12.
Children and adolescents on the autism spectrum display sensory disturbances, rigid and repetitive behavior, social communication problems and a high prevalence of impaired adaptive functioning. Autism is associated with slowed behavioral and neural habituation to repeated sensory input and decreased responses to sensory deviations. Mismatch negativity (MMN) reflects a pre-attentive difference in the neural response to sensory deviations relative to regularities and studies overall suggest that children and adolescents with autism tend to have smaller MMN. However, it remains unclear whether reduced MMN in autism is coupled to severity of specific autistic symptoms or more generally to lower level of adaptive functioning. To address these questions, the present study used electroencephalography (EEG) to assess whether auditory MMN in 59 children and adolescents with autism aged 7-14 years compared to 59 typically developing children and adolescents were related to specific autistic symptoms or level in adaptive functioning. As hypothesized, the autism group had a lower MMN amplitude than controls. Smaller MMN amplitudes were specifically associated with lower adaptive functioning in the autistic subjects but not in controls while no apparent relationships were observed with autistic-like social interaction and communication problems, atypical language, rigidity, stereotypy or sensory sensitivity symptoms. Our findings indicate that a blunted response to changes in sensory input may underlie or contribute to the generalized difficulties with adapting to daily life circumstances seen in children and adolescents with autism. LAY SUMMARY: Children and adolescents on the autism spectrum have a high prevalence of impaired adaptive functioning. Neuroimaging studies have reported that children and adolescents with autism display attenuated brain activity when discriminating sensory input. However, it is unknown whether this attenuation is related to autistic symptoms and/or adaptive functioning. The present study used electroencephalogram (EEG) to show that attenuated brain response in discrimination of novel compared to repetitive sounds in children and adolescents with autism is related to their impaired adaptive functioning.
自闭症谱系儿童和青少年表现出感官障碍、刻板和重复行为、社交沟通问题以及适应性功能受损的高患病率。自闭症与对重复感官输入的行为和神经习惯化减慢以及对感官偏差的反应降低有关。失匹配负波 (MMN) 反映了相对于规律性，对感官偏差的神经反应的前注意差异，并且总体研究表明，自闭症儿童和青少年的 MMN 往往较小。然而，自闭症中 MMN 的减少是否与特定自闭症症状的严重程度或更普遍的适应性功能水平相关仍不清楚。为了解决这些问题，本研究使用脑电图 (EEG) 来评估 59 名 7-14 岁自闭症儿童和青少年与 59 名典型发育儿童和青少年的听觉 MMN 是否与特定自闭症症状或适应性功能水平相关。正如假设的那样，自闭症组的 MMN 振幅低于对照组。自闭症组的 MMN 振幅较小与适应性功能降低有关，但对照组没有明显关系，而与自闭症样社交互动和沟通问题、非典型语言、刻板、刻板行为或感官敏感性症状没有明显关系。我们的发现表明，对感官输入变化的反应迟钝可能是自闭症儿童和青少年普遍存在适应日常生活困难的基础或促成因素。
解析：
“自闭症谱系”翻译为“autism spectrum”；
“感官障碍”翻译为“sensory disturbances”；
“刻板和重复行为”翻译为“rigid and repetitive behavior”；
“社交沟通问题”翻译为“social communication problems”；
“高患病率”翻译为“a high prevalence of”；
“适应性功能受损”翻译为“impaired adaptive functioning”；
“神经影像学”翻译为“neuroimaging”；
“attenuated brain activity”翻译为“attenuated brain activity”；
“大脑活动”翻译为“brain activity”；
“感知觉”翻译为“sensory”；
“反应迟钝”翻译为“attenuation”；
“相关”翻译为“be related to”；
“前注意差异”翻译为“pre-attentive difference”；
“失匹配负波”翻译为“mismatch negativity (MMN)”；
“神经反应”翻译为“neural response”；
“普遍性”翻译为“generalized”；
“日常生活”翻译为“daily life”；
“困难”翻译为“circumstances”；
“假设”翻译为“hypothesized”；
“脑电图”翻译为“electroencephalogram (EEG)”；
“表明”翻译为“show”；
“关系”翻译为“correlation”；
“听觉 MMN”翻译为“auditory MMN”；
“儿童和青少年”翻译为“children and adolescents”；
“典型发育”翻译为“typically developing”；
“普遍性”翻译为“general”；
“水平”翻译为“level”；
“与......相关”翻译为“be related to”；
“相比”翻译为“compared to”；
“刻板行为”翻译为“stereotypy”；
“感官敏感性”翻译为“sensory sensitivity”；
“表明”翻译为“indicate”；
“可能是......的基础或促成因素”翻译为“underlie or contribute to”；
