Bhatti Harneet, Cordova Sanchez Andres, Dhungana Rajat, Carvounis Christos, Singh Avneet
Internal Medicine, State University of New York Upstate Medical University, Syracuse, USA.
Cardiology, State University of New York Upstate Medical University, Syracuse, USA.
Cureus. 2022 Apr 9;14(4):e23986. doi: 10.7759/cureus.23986. eCollection 2022 Apr.
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2, is an ongoing pandemic that has affected millions globally. Many infected patients have been noted to have cardiovascular damage. Prior to the development of clinical symptoms, the use of transthoracic echocardiography, specifically with measurements of left ventricular global longitudinal strain (LVGLS), may provide an additional prognostic marker for patients infected with COVID-19. We sought to determine whether patients with COVID-19 and reduced LVGLS have an increased risk for mortality. The mean LVGLS was determined to be significantly lower in the non-survivors compared to the survivors (-11.6 ± 1.8 vs -15.4 ± 0.74, p<0.05). It should be noted, however, that even those that survived were found to have reduced LVGLS (<-18.5%). A multivariate logistic regression analysis was also performed that demonstrated a relationship between reduced LVGLS and an increased risk for mortality. Overall, our data indicate that COVID-19 patients may have subclinical left ventricular dysfunction, and that critically ill patients may have a greater decline in cardiac dysfunction.
2019冠状病毒病（COVID-19）由严重急性呼吸综合征冠状病毒2引起，是一场仍在全球范围内肆虐的大流行病，已影响数百万人。许多感染患者已被发现存在心血管损害。在临床症状出现之前，使用经胸超声心动图，特别是测量左心室整体纵向应变（LVGLS），可能为COVID-19感染患者提供额外的预后标志物。我们试图确定LVGLS降低的COVID-19患者是否有更高的死亡风险。结果发现，与幸存者相比，非幸存者的平均LVGLS显著更低（-11.6±1.8对-15.4±0.74，p<0.05）。然而，应该注意的是，即使是那些幸存者也被发现LVGLS降低（<-18.5%）。还进行了多因素逻辑回归分析，结果表明LVGLS降低与死亡风险增加之间存在关联。总体而言，我们的数据表明，COVID-19患者可能存在亚临床左心室功能障碍，危重症患者的心脏功能障碍可能下降得更严重。
