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采用反向原子转移自由基聚合法合成并表征含聚（磺基甜菜碱）的新型抗菌材料。

Synthesis and characterization of a novel antibacterial material containing poly(sulfobetaine) using reverse atom transfer radical polymerization.

作者信息

Chu Xiaohong, Zhang Ming, Zhou Ninglin, Wu Fan, Sun Baohong, Shen Jian

机构信息

Jiangsu Collaborative Innovation Center for Biological Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University Nanjing 210023 China

Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Engineering Research Center for Biomedical Function Materials Nanjing 210023 China.

出版信息

RSC Adv. 2018 Sep 25;8(58):33000-33009. doi: 10.1039/c8ra05793a. eCollection 2018 Sep 24.

DOI:10.1039/c8ra05793a
PMID:35548141
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9086390/
Abstract

A novel antibacterial agent was synthesized using 2-(dimethylamino)ethyl methacrylate (DM) and sodium 3-chloro-2-hydroxypropane sulfonate (CHPS). It was characterized by Fourier transform infrared spectroscopy (FTIR), NMR Spectroscopy (H NMR), and X-ray photoelectron spectroscopy (XPS). This new agent DMCHPS was then grafted onto a polyurethane (PU) substrate surface-initiated reverse atom transfer radical polymerization (SI-RATRP). The modified PU was characterized by FTIR and XPS. The hydrophilic properties of the PU surface before and after the incorporation of DMCHPS were determined by static contact angle (SCA) measurements. The results showed that the hydrophilicity of the PU surface after the modification was remarkably improved. MIC tests and bacterial adhesion confirmed that modified PU has good antibacterial properties. Protein adsorption experiments show that the material has a certain ability to resist pollution. Furthermore, the high survival rate of HEK293 human embryonic kidney cells shows that the modified PU has a potential use as a medicinal material.

摘要

使用甲基丙烯酸2-(二甲氨基)乙酯(DM)和3-氯-2-羟基丙烷磺酸钠(CHPS)合成了一种新型抗菌剂。通过傅里叶变换红外光谱(FTIR)、核磁共振光谱(H NMR)和X射线光电子能谱(XPS)对其进行了表征。然后通过表面引发反向原子转移自由基聚合(SI-RATRP)将这种新型试剂DMCHPS接枝到聚氨酯(PU)基材表面。通过FTIR和XPS对改性后的PU进行了表征。通过静态接触角(SCA)测量确定了引入DMCHPS前后PU表面的亲水性。结果表明，改性后PU表面的亲水性显著提高。MIC测试和细菌粘附证实改性后的PU具有良好的抗菌性能。蛋白质吸附实验表明该材料具有一定的抗污染能力。此外，HEK293人胚肾细胞的高存活率表明改性后的PU有作为药用材料的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/a2bf37e90655/c8ra05793a-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/3f5998f018fc/c8ra05793a-s1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/629f68dc36f3/c8ra05793a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/75d16d82f589/c8ra05793a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/1886c07fef6f/c8ra05793a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/9f3c993d0b82/c8ra05793a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/a2bf37e90655/c8ra05793a-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/3f5998f018fc/c8ra05793a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/5aec9a49625c/c8ra05793a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/856106a8485a/c8ra05793a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/355ee784b91e/c8ra05793a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/629f68dc36f3/c8ra05793a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/75d16d82f589/c8ra05793a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/1886c07fef6f/c8ra05793a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/9f3c993d0b82/c8ra05793a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d78/9086390/a2bf37e90655/c8ra05793a-f8.jpg

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