通过 SI-RATRP 用聚（2-甲基丙烯酰氧乙基磷酸胆碱）改性的抗凝血性聚氨酯基底。
Anticoagulant polyurethane substrates modified with poly(2-methacryloyloxyethyl phosphorylcholine) via SI-RATRP.
机构信息
Jiangsu Collaborative Innovation Center for Biological Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing 210023, China.
Jiangsu Collaborative Innovation Center for Biological Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing 210023, China; Nanjing Zhou Ninglin Advanced Materials Technology Company Limited, Nanjing 211505, China.
出版信息
Colloids Surf B Biointerfaces. 2018 Mar 1;163:301-308. doi: 10.1016/j.colsurfb.2018.01.005. Epub 2018 Jan 8.
A novel catalyst system of Reverse Atom Transfer Radical Polymerization (RATRP) to prepare Polyurethane (PU) films modified by poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC) was studied in this article. In this system, PU film was pretreated by LaCl/CA ethanol solution to obtain a hydrated surface allowing more initiators to be immobilized on it. Moreover, complexes composed of silane coupling agent 3-chloropropyltrimethoxysilane (CPTM), chlorhexidine acetate (CA) and lanthanum(III) worked as ligands of copper ions as a whole during RATRP process. PU films before and after modification were characterized by X-ray photoelectron spectroscopy (XPS) and static contact angle (SCA) to confirm that pMPC chains were successfully grafted from the substrates. Results of Plasma recalcification time assay, platelet adhesion test indicated excellent blood compatibility. Furthermore, the antibacterial activity of the material have been improved which proved by adhesion test of E.coil.
本文研究了一种新型的反向原子转移自由基聚合（RATRP）催化剂体系，用于制备聚（2-甲基丙烯酰氧乙基磷酸胆碱）（pMPC）改性的聚氨酯（PU）薄膜。在该体系中，通过 LaCl/CA 乙醇溶液预处理 PU 薄膜，使其表面水合，从而固定更多的引发剂。此外，硅烷偶联剂 3-氯丙基三甲氧基硅烷（CPTM）、醋酸洗必泰（CA）和镧（III）组成的配合物在 RATRP 过程中作为铜离子的配体整体起作用。通过 X 射线光电子能谱（XPS）和静态接触角（SCA）对修饰前后的 PU 薄膜进行了表征，证实了 pMPC 链已成功从基底上接枝。血浆复钙时间测定和血小板黏附试验结果表明，该材料具有良好的血液相容性。此外，通过对 E.coil 的黏附试验证明了该材料的抗菌活性得到了提高。
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