Das Ashok Kumar, Kuchi Rambabu, Van Phuoc Cao, Sohn Youngku, Jeong Jong-Ryul
Department of Chemistry, Chungnam National University Daejeon 34134 South Korea
Department of Materials Science and Engineering, Graduate School of Energy Science and Technology, Chungnam National University Daejeon 34134 South Korea
RSC Adv. 2018 Sep 4;8(54):31037-31047. doi: 10.1039/c8ra05885g. eCollection 2018 Aug 30.
Abnormal levels of dopamine (DA) in body fluids is an indication of serious health issues, hence development of highly sensitive platforms for the precise detection of DA is highly essential. Herein, we demonstrate an FeO@Cu silicate based electrochemical sensing platform for the detection of DA. Morphology and BET analysis shows the formation of ∼320 nm sized sea urchin-like FeO@Cu silicate core-shell nanostructures with a 174.5 m g surface area. Compared to FeO and FeO@SiO, the FeO@Cu silicate urchins delivered enhanced performance towards the electrochemical sensing of DA in neutral pH. The FeO@Cu silicate sensor has a 1.37 μA μM cm sensitivity, 100-700 μM linear range and 3.2 μM limit of detection (LOD). In addition, the proposed FeO@Cu silicate DA sensor also has good stability, selectivity, reproducibility and repeatability. The presence of Cu in FeO@Cu silicate and the negatively charged surface of the Cu silicate shell play a vital role in achieving high selectivity and sensitivity during DA sensing. The current investigation not only represents the development of a highly selective DA sensor but also directs towards the possibility for the fabrication of other Cu silicate based core-shell nanostructures for the precise detection of DA.
体液中多巴胺（DA）水平异常表明存在严重健康问题，因此开发用于精确检测DA的高灵敏度平台至关重要。在此，我们展示了一种基于FeO@Cu硅酸盐的电化学传感平台用于检测DA。形态学和BET分析表明形成了尺寸约为320 nm的海胆状FeO@Cu硅酸盐核壳纳米结构，其表面积为174.5 m²/g。与FeO和FeO@SiO相比，FeO@Cu硅酸盐海胆在中性pH条件下对DA的电化学传感表现出增强的性能。FeO@Cu硅酸盐传感器具有1.37 μA μM⁻¹ cm⁻²的灵敏度、100 - 700 μM的线性范围和3.2 μM的检测限（LOD）。此外，所提出的FeO@Cu硅酸盐DA传感器还具有良好的稳定性、选择性、重现性和重复性。FeO@Cu硅酸盐中Cu的存在以及Cu硅酸盐壳的带负电表面在DA传感过程中实现高选择性和灵敏度方面起着至关重要的作用。当前的研究不仅代表了一种高选择性DA传感器的开发，还指向了制造其他基于Cu硅酸盐的核壳纳米结构用于精确检测DA的可能性。
