Jiang Yanan, Zhang Xin, Zhang Wei, Wang Menghao, Yan Liwei, Wang Kefeng, Han Lu, Lu Xiong
School of Materials Science and Engineering, Key Lab of Advanced Technologies of Materials, Ministry of Education, Yibin Institute of Southwest Jiaotong University, Southwest Jiaotong University, Chengdu 610031, Sichuan, China.
Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China.
ACS Nano. 2022 Jun 28;16(6):8662-8676. doi: 10.1021/acsnano.2c00662. Epub 2022 May 13.
Adhesive-caused injury is a great threat for infants with premature skin or diabetic patients with fragile skin because extra-strong adhesion might incur pain, inflammation, and exacerbate trauma upon removal. Herein, we present a skin-friendly adhesive hydrogel patch based on protein-polyphenol complexation strategy, which leads to a thermoresponsive network sensitive to body temperature. The adhesion of the hydrogel is smartly activated after contacting with warm skin, whereas the painless detachment is easily realized by placing an ice bag on the surface of the hydrogel. The hydrogel exhibits an immunomodulatory performance that prevents irritation and allergic reactions during long-period contact with the skin. Thus, the hydrogel patch works as a conformable and nonirritating interface to guarantee nondestructively securing bioelectronics on infant skin for healthcare. Furthermore, the hydrogel patch provides gentle adhesion to wounded skin and provides a favorable environment to speed up the healing process for managing diabetic wounds.
粘合剂引起的损伤对皮肤娇嫩的早产儿或糖尿病患者构成巨大威胁，因为超强的粘附力可能会在去除时引起疼痛、炎症并加重创伤。在此，我们提出了一种基于蛋白质-多酚络合策略的亲肤粘合剂水凝胶贴片，该策略可形成对体温敏感的热响应网络。水凝胶与温暖的皮肤接触后，其粘附力会被智能激活，而通过在水凝胶表面放置冰袋即可轻松实现无痛剥离。该水凝胶具有免疫调节性能，可防止在与皮肤长期接触过程中产生刺激和过敏反应。因此，水凝胶贴片作为一种贴合且无刺激性的界面，可确保将生物电子器件无损地固定在婴儿皮肤上用于医疗保健。此外，水凝胶贴片对受伤皮肤具有温和的粘附力，并为加速糖尿病伤口的愈合过程提供了有利环境。
