Mooradian A D, Morley J E
Am J Clin Nutr. 1987 May;45(5):877-95. doi: 10.1093/ajcn/45.5.877.
Diabetes mellitus is a chronic metabolic disorder, which can alter the nutritional status of the individual. Some micronutrients, in particular zinc and chromium, have been implicated in the pathogenesis of carbohydrate intolerance. This review evaluates the available published data on the status of 10 mineral elements and seven vitamins in diabetic patients and experimental animal models of diabetes. The role of these micronutrients in insulin secretion and carbohydrate metabolism is discussed in an attempt to determine whether the reported alterations in serum or tissue content of minerals or vitamins contribute to the carbohydrate intolerance of diabetic patients. It is concluded that both Type I and Type II diabetes mellitus can result in changes in certain micronutrients. However, adequately controlled studies to establish the role of trace elements in the pathogenesis of diabetes mellitus are not available.
糖尿病是一种慢性代谢紊乱疾病，它会改变个体的营养状况。一些微量营养素，特别是锌和铬，与碳水化合物不耐受的发病机制有关。这篇综述评估了已发表的关于糖尿病患者和糖尿病实验动物模型中10种矿物质元素和7种维生素状况的数据。讨论了这些微量营养素在胰岛素分泌和碳水化合物代谢中的作用，试图确定所报道的矿物质或维生素血清或组织含量的改变是否导致糖尿病患者的碳水化合物不耐受。得出的结论是，I型和II型糖尿病都会导致某些微量营养素的变化。然而，目前尚无充分对照的研究来确定微量元素在糖尿病发病机制中的作用。
