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LINC00467 下调 Reprimo 参与胃癌的生长和转移。

Downregulated Reprimo by LINC00467 participates in the growth and metastasis of gastric cancer.

机构信息

Department of Oncology, Cangzhou Central Hospital, Cangzhou, Hebei, China.

Department of Ultrasound, Cangzhou Central HospitalThe 1st, Cangzhou, Hebei, China.

出版信息

Bioengineered. 2022 May;13(5):11893-11906. doi: 10.1080/21655979.2022.2063662.

DOI:10.1080/21655979.2022.2063662
PMID:35549646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9276005/
Abstract

Gastric cancer (GC) as an aggressive malignancy still causes a global health problem. It has been documented that long noncoding RNAs are involved in GC development. Therefore, this research was designed to explore the role of LINC00467 in the growth and metastasis of GC. The expression of LINC00467 and Reprimo in GC tissues and cells was detected. The binding relationship among LINC00467, DNA methyltransferase 1 (DNMT1) and Reprimo was assessed following. Reprimo promoter methylation was detected by methylation sequencing. GC cell lines overexpressing or knock downing LINC00467 were constructed for pinpointing the effect of LINC00467 on cell functions as well as growth and metastasis of GC cells . LINC00467 was highly expressed, whereas Reprimo was poorly expressed in GC tissues and cells. Mechanically, LINC00467 promoted the methylation and decreased the expression of Reprimo promoter by recruiting DNMT1 in GC cells. Knockdown of LINC00467 diminished the malignant properties of GC cells. Knockdown of LINC00467 reduced tumorigenesis and metastasis of GC cells . LINC00467 might exert oncogenic effects in GC via Reprimo downregulation by recruiting DNMT1.

摘要

胃癌（GC）作为一种侵袭性恶性肿瘤仍然是一个全球性的健康问题。有文献记载，长链非编码 RNA 参与了 GC 的发生发展。因此，本研究旨在探讨 LINC00467 在 GC 生长和转移中的作用。检测了 LINC00467 和 Reprimo 在 GC 组织和细胞中的表达。评估了 LINC00467 与 DNA 甲基转移酶 1（DNMT1）和 Reprimo 之间的结合关系。通过甲基化测序检测 Reprimo 启动子的甲基化。构建了过表达或敲低 LINC00467 的 GC 细胞系，以确定 LINC00467 对细胞功能以及 GC 细胞生长和转移的影响。LINC00467 在 GC 组织和细胞中高表达，而 Reprimo 表达水平较低。在 GC 细胞中，LINC00467 通过招募 DNMT1 促进 Reprimo 启动子的甲基化和降低其表达。敲低 LINC00467 可减弱 GC 细胞的恶性特性。敲低 LINC00467 可降低 GC 细胞的致瘤性和转移能力。LINC00467 可能通过招募 DNMT1 下调 Reprimo 发挥致癌作用在 GC 中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/6cbf607be7d0/KBIE_A_2063662_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/040c31046f35/KBIE_A_2063662_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/79e226811ab8/KBIE_A_2063662_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/ea299db27998/KBIE_A_2063662_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/d3d573d24609/KBIE_A_2063662_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/bc54fa810399/KBIE_A_2063662_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/13edd679693d/KBIE_A_2063662_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/6cbf607be7d0/KBIE_A_2063662_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/040c31046f35/KBIE_A_2063662_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/79e226811ab8/KBIE_A_2063662_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/ea299db27998/KBIE_A_2063662_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/d3d573d24609/KBIE_A_2063662_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/bc54fa810399/KBIE_A_2063662_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/13edd679693d/KBIE_A_2063662_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acde/9276005/6cbf607be7d0/KBIE_A_2063662_F0006_OC.jpg

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本文引用的文献

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Front Oncol. 2021 Dec 13;11:709044. doi: 10.3389/fonc.2021.709044. eCollection 2021.
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