线粒体靶向荧光探针用于活细胞中外源和内源性甲基乙二醛的可视化。
Mitochondria-targeted fluorescent probe for visualization of exogenous and endogenous methylglyoxal in living cells.
机构信息
Tianjin Key Laboratory for Photoelectric Materials and Devices, and Key Laboratory of Display Materials & Photoelectric Devices, Ministry of Education, School of Materials Science & Engineering, Tianjin University of Technology, Tianjin, 300384, China.
School of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150001, China.
出版信息
Chem Commun (Camb). 2022 May 30;58(44):6453-6456. doi: 10.1039/d2cc01503j.
An activatable mitochondria-targeted fluorescent probe Hcy-OPD was synthesized for the detection of methylglyoxal (MGO). For the introduction of a preorganized isopropylamino group on the aromatic -diamine framework to regulate the hindrance effect, Hcy-OPD showed high selectivity and sensitivity (0.22 μM) for monitoring MGO. The probe can be applied successfully in the imaging of exogenous and endogenous MGO in living cells.
一种可激活的靶向线粒体荧光探针 Hcy-OPD 被合成用于检测甲基乙二醛 (MGO)。为了在芳基二胺骨架上引入预组织的异丙基氨基基团以调节阻碍效应，Hcy-OPD 对监测 MGO 表现出高选择性和灵敏度（0.22 μM）。该探针可成功应用于活细胞中外源和内源性 MGO 的成像。
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