School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.
Org Biomol Chem. 2022 Jun 15;20(23):4782-4786. doi: 10.1039/d2ob00698g.
A novel near-infrared fluorescent probe (SWJT-2) has been designed and synthesized for the detection of methylglyoxal (MGO). It showed a low detection limit (0.32 μM), high selectivity and the fastest detection (15 min) over various reactive carbonyl compounds in aqueous solution. SWJT-2 had been successfully applied to bioimaging in HeLa cells to detect exogenous and endogenous MGO.
一种新型的近红外荧光探针（SWJT-2）已被设计和合成，用于检测甲基乙二醛（MGO）。它在水溶液中对各种活性羰基化合物表现出低检测限（0.32 μM）、高选择性和最快的检测速度（15 分钟）。SWJT-2 已成功应用于 HeLa 细胞的生物成像，以检测外源性和内源性 MGO。
