College of Food Science and Engineering, Northwest A&F University, No. 22 Xinong Road, Yangling, Shaanxi, 712100, China.
Lab of Meat Processing and Quality Control of EDU, College of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China.
Biomaterials. 2022 Jun;285:121546. doi: 10.1016/j.biomaterials.2022.121546. Epub 2022 Apr 29.
Great challenges remain in the effective control of irregular and incompressible deep wound bleeding and the promotion of wound healing after bacterial infection. In this study, cryogels were prepared using an ice template based on chitosan (CS), oxidized gallic acid (OGA) and hemin (HE), which are all green edible materials. The cryogels exhibit rapid blood-triggered shape recovery and a high swelling ratio. The cryogels with 5 mg mL HE (Gel-CS/OGA@HE5) exert excellent photothermal effects. Additionally, the cryogels have excellent cytocompatibility and blood clotting abilities. In the mouse liver injury model and mouse tail amputation model, Gel-CS/OGA@HE5 presents better hemostasis properties than gauze and a gelatin sponge. Moreover, Gel-CS/OGA@HE5 displays excellent healing performance as a wound dressing. Overall, we provide a simple and effective strategy to prepare cryogels for controlling wound bleeding and promoting wound healing.
在有效控制不规则且不可压缩的深部伤口出血和促进细菌感染后伤口愈合方面仍然存在巨大挑战。在这项研究中，基于壳聚糖 (CS)、氧化没食子酸 (OGA) 和血红素 (HE) 制备了冷冻凝胶，这些都是绿色可食用材料。冷冻凝胶具有快速的血液触发形状恢复和高溶胀比。含有 5mg/mL HE 的冷冻凝胶（Gel-CS/OGA@HE5）表现出优异的光热效应。此外，冷冻凝胶具有优异的细胞相容性和凝血能力。在小鼠肝损伤模型和小鼠尾切断模型中，Gel-CS/OGA@HE5 比纱布和明胶海绵具有更好的止血性能。此外，Gel-CS/OGA@HE5 作为伤口敷料表现出优异的愈合性能。总的来说，我们提供了一种简单有效的策略来制备用于控制伤口出血和促进伤口愈合的冷冻凝胶。
