School of Medicine, South China University of Technology, Guangzhou, 510006, China.
Department of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Adv Sci (Weinh). 2023 Nov;10(31):e2304243. doi: 10.1002/advs.202304243. Epub 2023 Sep 4.
Due to the complex microenvironment and healing process of diabetic wounds, developing wound dressing with good biocompatibility, mechanical stability, breathability, exudate management, antibacterial ability, and immunomodulatory property is highly desired but remains a huge challenge. Herein, a multifunctional cryogel is designed and prepared with bio-friendly bacterial cellulose, gelatin, and dopamine under the condition of sodium periodate oxidation. Bacterial cellulose can enhance the mechanical stability of the cryogel by improving the skeleton supporting effect and crosslinking degree. The cryogel shows outstanding breathability and exudate management capability thanks to the interpenetrated porous structures. I and sodium iodides produced in situ by reduction of sodium periodate provide efficient antibacterial properties for the cryogel. The cryogel facilitates macrophage polarization from M1 to M2, thus regulating the immune microenvironment of infected diabetic wounds. With these advantages, the multifunctional cryogel effectively promotes collagen deposition and neovascularization, thus accelerating the healing of infected diabetic wounds.
由于糖尿病伤口的复杂微环境和愈合过程，开发具有良好生物相容性、机械稳定性、透气性、渗出液管理能力、抗菌能力和免疫调节特性的伤口敷料是非常需要的，但仍然是一个巨大的挑战。在此，通过在高碘酸钠氧化条件下使用生物友好型细菌纤维素、明胶和多巴胺设计并制备了一种多功能水凝胶。细菌纤维素可以通过提高骨架支撑作用和交联度来增强水凝胶的机械稳定性。由于互穿的多孔结构，水凝胶表现出出色的透气性和渗出液管理能力。原位还原生成的碘离子和碘酸钠为水凝胶提供了有效的抗菌性能。水凝胶促进巨噬细胞从 M1 向 M2 极化，从而调节感染性糖尿病伤口的免疫微环境。具有这些优点的多功能水凝胶可有效促进胶原蛋白沉积和新血管生成，从而加速感染性糖尿病伤口的愈合。
