Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Sleep. 2022 May 12;45(5). doi: 10.1093/sleep/zsac047. Epub 2022 Feb 28.
Recent electron microscopic analyses of neurons in the Drosophila and rodent brain demonstrate that acute or chronic sleep loss can alter the structures of various organelles, including mitochondria, nucleus, and Golgi apparatus. Here, we discuss these findings in the context of biochemical findings from the sleep deprived brain, to clarify how these morphological changes may related to altered organelle function. We discuss how, taken together, the available data suggest that sleep loss (particularly chronic sleep loss) disrupts such fundamental cellular processes as transcription, translation, intracellular transport, and metabolism. A better understanding of these effects will have broad implications for understanding the biological importance of sleep, and the relationship of sleep loss to neuropathology.
最近对果蝇和啮齿动物大脑神经元的电子显微镜分析表明，急性或慢性睡眠剥夺会改变各种细胞器的结构，包括线粒体、细胞核和高尔基体。在这里，我们根据剥夺睡眠大脑的生化发现来讨论这些发现，以阐明这些形态变化如何与细胞器功能改变相关。我们讨论了这些数据如何共同表明，睡眠剥夺（特别是慢性睡眠剥夺）会破坏转录、翻译、细胞内运输和代谢等基本细胞过程。更好地理解这些影响将对理解睡眠的生物学重要性以及睡眠剥夺与神经病理学的关系产生广泛影响。
