College of Science and Engineering, Flinders University, Adelaide, SA, Australia.
Flinders Health and Medical Research Institute Sleep Health/Adelaide Institute for Sleep Health, Flinders University, College of Medicine and Public Health Adelaide, SA, Australia.
Sleep. 2022 May 12;45(5). doi: 10.1093/sleep/zsac051. Epub 2022 Mar 4.
To determine if a novel EEG-derived continuous index of sleep depth/alertness, the odds ratio product (ORP), predicts self-reported daytime sleepiness and poor sleep quality in two large population-based cohorts.
ORP values which range from 0 (deep sleep) to 2.5 (fully alert) were calculated in 3s intervals during awake periods (ORPwake) and NREM sleep (ORPNREM) determined from home sleep studies in the HypnoLaus (N = 2162: 1106 females, 1056 males) and men androgen inflammation lifestyle environment and stress (MAILES) cohorts (N = 754 males). Logistic regression was used to examine associations between ORPwake, ORPNREM, and traditional polysomnography measures (as comparators) with excessive sleepiness (Epworth sleepiness scale >10) and poor sleep quality (Pittsburgh sleep quality index >5) and insomnia symptoms.
High ORPwake was associated with a ~30% increase in poor sleep quality in both HypnoLaus (odds ratio, OR, and 95% CI) 1.28 (1.09, 1.51), and MAILES 1.36 (1.10, 1.68). High ORPwake was also associated with a ~28% decrease in excessive daytime sleepiness in the MAILES dataset. ORPNREM was associated with a ~30% increase in poor sleep quality in HypnoLaus but not in MAILES. No consistent associations across cohorts were detected using traditional polysomnography markers.
ORP, a novel EEG-derived metric, measured during wake periods predicts poor sleep quality in two independent cohorts. Consistent with insomnia symptomatology of poor perceived sleep in the absence of excessive daytime sleepiness, ORPwake may provide valuable objective mechanistic insight into physiological hyperarousal.
确定一种新的脑电图衍生的睡眠深度/警觉连续指数——优势比乘积（ORP），是否可以预测两个大型基于人群的队列中自我报告的日间嗜睡和睡眠质量差。
在 HypnoLaus（N=2162：1106 名女性，1056 名男性）和男性雄激素炎症生活方式环境和压力（MAILES）队列（N=754 名男性）的家庭睡眠研究中，在清醒期间（ORPwake）和非快速眼动睡眠（ORPNREM）中以 3 秒间隔计算 ORP 值，范围从 0（深度睡眠）到 2.5（完全警觉）。使用逻辑回归检查 ORPwake、ORPNREM 和传统多导睡眠图测量值（作为对照）与过度嗜睡（嗜睡量表评分>10）和睡眠质量差（匹兹堡睡眠质量指数>5）和失眠症状之间的关联。
高 ORPwake 与 HypnoLaus（比值比[OR]和 95%置信区间）中的睡眠质量差增加约 30%相关，1.28（1.09，1.51），和 MAILES 1.36（1.10，1.68）。高 ORPwake 也与 MAILES 数据集过度日间嗜睡的约 28%减少相关。ORPNREM 与 HypnoLaus 中睡眠质量差增加约 30%相关，但在 MAILES 中则不然。使用传统多导睡眠图标志物未在两个队列中检测到一致的关联。
ORP，一种新的脑电图衍生的测量指标，在两个独立的队列中测量，可预测睡眠质量差。与缺乏过度日间嗜睡的睡眠感觉不佳的失眠症状一致，ORPwake 可能为生理过度唤醒提供有价值的客观机制见解。
